LGS transports from the nucleus to the cytosol

Stable Identifier
R-DME-209303
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
nuclear envelope, cytosol, nucleoplasm
ReviewStatus
5/5
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LGS transports from the nucleus to the cytosol
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The free Legless (LGS) protein exports from the nucleus to the cytoplasm by an unknown mechanism potentially with additional interaction partners, where it can now target Armadillo (ARM), which is now not being rapidly removed from the cytoplasm by the 'destruction complex'.
Literature References
PubMed ID Title Journal Year
16554443 Nucleo-cytoplasmic distribution of beta-catenin is regulated by retention

Behrens, J, Mayr, B, Krieghoff, E

J Cell Sci 2006
15208637 Pygopus and Legless target Armadillo/beta-catenin to the nucleus to enable its transcriptional co-activator function

Bienz, M, Cliffe, A, Townsley, FM

Nat Cell Biol 2004
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Authored
Williams, MG  (2006-07-26)
Reviewed
Nusse, R  (2008-01-19)
Created
Williams, MG  (2006-06-28)
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