Formation of the 'scaffold complex'

Stable Identifier
R-DME-209331
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The kinesin-related protein, Costal2 (COS), forms a microtubule-associated 'scaffold complex' with Cubitus Interruptus (CI) and the Ser/Thr protein kinase Fused (FU). CI also associates directly with the Supressor of Fused (SU(FU)) protein in a separate complex. Complexes containing CI, COS, FU and SU(FU) are detectable but rare. The Ser/Thr protein kinases: Protein kinase A (PKA-C1), Shaggy (SGG), Casein kinase I alpha (CKIalpha), and Casein kinase I epsilon (DCO) all bind to the scaffold protein COS.
Literature References
PubMed ID Title Journal Year
15063184 Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms

Wang, G, Jiang, J

Dev Biol 2004
15691767 Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus

Tong, C, Wang, G, Zhang, W, Zhao, Y, Wang, B, Jiang, J, Jia, J

Dev Cell 2005
14636583 Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2

Beachy, PA, Weis-Garcia, F, Oh, S, Wang, B, Lum, L, Zhang, C, Taipale, J, von Kessler, DP, Gong, R, Mann, RK

Mol Cell 2003
11914126 Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2

Plessis, A, Sanial, M, Monnier, V, Ho, KS, Scott, MP

BMC Dev Biol 2002
11090136 Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus

Wang, G, Wang, B, Jiang, J, Amanai, K

Genes Dev 2000
9601642 Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway

Plessis, A, Dussillol, F, Monnier, V, Alves, G, Lamour-Isnard, C

Curr Biol 1998
10825151 Identification of a tetrameric hedgehog signaling complex

Sosinski, J, Elangovan, G, Robbins, DJ, Cheng, Y, Vallance, JE, Stegman, MA

J Biol Chem 2000
11955435 Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1

Price, MA, Kalderon, D

Cell 2002
Participants
Participates
Authored
Reviewed
Created
Cite Us!