LGS dissociates from the PYGO complex

Stable Identifier
R-DME-209332
Type
Reaction [dissociation]
Species
Drosophila melanogaster
Compartment
nucleoplasm
ReviewStatus
5/5
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LGS dissociates from the PYGO complex
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The inactivation and destabilisation of the 'destruction complex' means elevated levels of cytoplasmic Armadillo (ARM). In the nucleus, the protein Legless (LGS) dissociates from its nuclear anchor, Pygopus (PYGO).
Literature References
PubMed ID Title Journal Year
16554443 Nucleo-cytoplasmic distribution of beta-catenin is regulated by retention

Behrens, J, Mayr, B, Krieghoff, E

J Cell Sci 2006
15208637 Pygopus and Legless target Armadillo/beta-catenin to the nucleus to enable its transcriptional co-activator function

Bienz, M, Cliffe, A, Townsley, FM

Nat Cell Biol 2004
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Authored
Williams, MG  (2006-07-26)
Reviewed
Nusse, R  (2008-01-19)
Created
Williams, MG  (2006-06-28)
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