Assembly of the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'

Stable Identifier
R-DME-214405
Type
Reaction
Species
Drosophila melanogaster
Compartment
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Summation

Upon monomeric peptidoglycan (PGN) binding and receptor multimerisation in the cytosol, a 'signalling complex' is assembled. The adaptor protein, IMD, binds to the PGRP-LE receptors, while another adaptor protein, DFADD (BG4), binds to IMD through their respective death domains. The caspase-8 orthologue, DREDD, binds to BG4 through interaction between their respective death-inducing (DID) domains.

Participants
Participant Of
Inferred From