Monomeric PGN binds to PGRP-LE in the cytosol

Stable Identifier
R-DME-214410
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
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Monomeric PGN binds to PGRP-LE in the cytosol
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Peptidoglycan recognition protein, PGRP-LE receptor contains no predicted transmembrane domain or signal sequence and so is predicted to be an intracellular receptor. The recognition of the monomeric diaminopimelic acid (DAP)-type peptidoglycan (PGN) tracheal cytotoxin, TCT by PGRP-LE occurs intracellularly. However, it is postulated that the PGRP domain of a truncated PGRP-LE can also function outside the cell in a CD14-like manner by presenting DAP-type PGNs to cell surface PGRP-LC receptors.
Literature References
PubMed ID Title Journal Year
16767093 PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan

Yano, T, Kaneko, T, Silverman, N, Lim, JH, Kurata, S, Peach, C, Oshima, Y, Aggarwal, K, Goldman, WE, Ueda, K, Erturk-Hasdemir, D, Oh, BH

Nat Immunol 2006
16428381 Structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteins

Yano, T, Silverman, N, Lim, JH, Kurata, S, Oshima, Y, Kim, HE, Aggarwal, K, Goldman, WE, Kim, MS, Oh, BH

J Biol Chem 2006
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Authored
Williams, MG  (2007-07-11)
Reviewed
Lemaitre, B  (2008-06-20)
Silverman, N  (2008-06-20)
Created
Williams, MG  (2008-02-26)
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