RDX binds to and ubiquitinates CI

Stable Identifier
Reaction [transition]
Drosophila melanogaster
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HIB or Roadkill (RDX) is transcriptionally induced by Hedgehog signalling and binds directly to Cubitus Interruptus (CI), likely in competition with Supressor of Fused (SU(FU)), to link CI with a Cul3 aka guftagu (GFT)-based E3 ubiquitin ligase complex, leading to degradation of active nuclear CI.

Literature References
PubMed ID Title Journal Year
15331761 Targeted disruption of Drosophila Roc1b reveals functional differences in the Roc subunit of Cullin-dependent E3 ubiquitin ligases

Donaldson, TD, Noureddine, MA, Reynolds, PJ, Bradford, W, Duronio, RJ

Mol Biol Cell 2004
16651542 Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus

Kent, D, Bush, EW, Hooper, JE

Development 2006
17102630 Regulation of Hh/Gli signaling by dual ubiquitin pathways

Jiang, J

Cell Cycle 2006
16740475 A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor

Zhang, Q, Zhang, L, Wang, B, Ou, CY, Chien, CT, Jiang, J

Dev Cell 2006
Catalyst Activity

ubiquitin-protein transferase activity of RDX:GFT:ROC1B [nucleoplasm]

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