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p-SHC1:GRB2:SOS [cytosol]
Stable Identifier
R-DME-2685672
Type
Complex
Species
Drosophila melanogaster
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
DAP12 interactions (Drosophila melanogaster)
DAP12 signaling (Drosophila melanogaster)
Activation of RAC1 by VAV2/3 (Drosophila melanogaster)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
Recruitment of GADS:SLP-76 to p-5Y-LAT (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
Recruitment of VAV and BTK to p-SLP-76 (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
Release of p-PLCG1 (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
SOS mediated nucleotide exchange of RAS (SHC) (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
FCERI mediated Ca+2 mobilization (Drosophila melanogaster)
Autophosphorylation of BTK/ITK (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
Hydrolysis of PIP2 by PLCG (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
FCERI mediated MAPK activation (Drosophila melanogaster)
Activation of RAC1 by VAV (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
Autophosphorylation of PAK (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
Interaction of GRB2:SOS complex with p-SHC1 (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
Phosphorylation and activation of VAV (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
Recruitment of GADS:SLP-76 to p-5Y-LAT (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
Recruitment of PAK to the membrane by binding active RAC1 (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
Recruitment of VAV to p-SLP-76 (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
SOS mediated nucleotide exchange of RAS (SHC) (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
Role of LAT2/NTAL/LAB on calcium mobilization (Drosophila melanogaster)
PI3K associates with phosphorylated GAB2 (Drosophila melanogaster)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Drosophila melanogaster)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Drosophila melanogaster)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Drosophila melanogaster)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
Phosphorylation of PIP2 to PIP3 by PI3K (Drosophila melanogaster)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Drosophila melanogaster)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Drosophila melanogaster)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
RAS GEFs promote RAS nucleotide exchange (Drosophila melanogaster)
RAS GEFs [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
GRB2-1:SOS1 [cytosol]
(Drosophila melanogaster)
phospho-Shc [cytosol]
(Drosophila melanogaster)
Participates
as a component of
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
as an output of
Interaction of GRB2:SOS complex with p-SHC1 (Drosophila melanogaster)
Inferred From
p-SHC1:GRB2:SOS [cytosol]
(Homo sapiens)
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