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RHO1 GTPase cycle
Stable Identifier
R-DME-350407
Type
Pathway
Species
Drosophila melanogaster
ReviewStatus
5/5
Locations in the PathwayBrowser
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Drosophila signaling pathways (Drosophila melanogaster)
Planar Cell Polarity pathway (Drosophila melanogaster)
Activation of Downstream Effectors (Drosophila melanogaster)
RHO1 signalling (Drosophila melanogaster)
RHO1 GTPase cycle (Drosophila melanogaster)
General
SBML
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Spatzle (SPZ) dimer binding leads to Toll (TL) receptor homodimerisation and activation.
Literature References
PubMed ID
Title
Journal
Year
17574020
Planar polarity and tissue morphogenesis
Zallen, JA
Cell
2007
17563758
Planar cell polarity: one or two pathways?
Casal, J
,
Struhl, G
,
Lawrence, PA
Nat Rev Genet
2007
Participants
Events
RHOGEF2 binds to RHO1:GDP complex at the plasma membrane
(Drosophila melanogaster)
RHOGEF2 stimulates nucleotide exchange of RHO1:GDP complex
(Drosophila melanogaster)
RHO1:GTP complex dissociates from RHOGEF2
(Drosophila melanogaster)
RHOGAPP190 binds to RHO1:GTP complex at the plasma membrane
(Drosophila melanogaster)
RHOGAPP190 activates GTP hydrolysis by RHO1:GTP
(Drosophila melanogaster)
RHO1:GDP complex dissociates from RHOGAPP190
(Drosophila melanogaster)
RHOGDI binds to and sequesters RHO1:GDP complex to the cytosol
(Drosophila melanogaster)
RHO1:GDP complex dissociates from RHOGDI and binds to the plasma membrane
(Drosophila melanogaster)
Participates
as an event of
RHO1 signalling (Drosophila melanogaster)
Authored
Williams, MG (2008-05-20)
Reviewed
Axelrod, JD (2009-11-19)
Created
Williams, MG (2008-05-19)
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