AP-1 transcription factor forms a complex with STAT92E and DSP1 which displaces REL-68 from its target gene

Stable Identifier
R-DME-354273
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
nucleoplasm
ReviewStatus
5/5
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AP-1 transcription factor forms a complex with STAT92E and DSP1 which displaces REL-68 from its target gene
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When the JNK pathway is activated, the AP-1 transcription factor, a complex Jun-related antigen (JRA) and Kayak (KAY), forms a complex with the HMG protein, dorsal switch protein (DSP1) and STAT92E transcription factor (involved in the JAK/STAT pathway). This 'repressosome complex' and phosphorylated Relish (REL-68) are mutually exclusive in binding to this gene and so phosphorylated REL-68 is displaced from its target gene.
Literature References
PubMed ID Title Journal Year
15640802 Downregulation of lipopolysaccharide response in Drosophila by negative crosstalk between the AP1 and NF-kappaB signaling modules

Kim, YJ, Kim, J, Kim, T, Yoon, J, Yoon, JH, Song, YH, Kim-Ha, J, Lee, WB, Cho, H, Kim, SN

Nat Immunol 2005
17803358 Down-regulation of NF-kappaB target genes by the AP-1 and STAT complex during the innate immune response in Drosophila

Kim, YJ, Shim, J, Cho, HS, Kim, J, Kim, LK, Choi, UY, Kim-Ha, J, Lee, WB, Lee, JS, Jeong, K

PLoS Biol 2007
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Authored
Williams, MG  (2007-07-11)
Reviewed
Lemaitre, B  (2008-06-20)
Silverman, N  (2008-06-20)
Created
Williams, MG  (2008-06-17)
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