Reactome | VAChT [plasma membrane]

VAChT [plasma membrane]

Stable Identifier

R-DME-372513

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

plasma membrane

Synonyms

SLC18A3, O17444

Locations in the PathwayBrowser

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Vesicle-mediated transport (Drosophila melanogaster)

- Membrane Trafficking (Drosophila melanogaster)
  - Clathrin-mediated endocytosis (Drosophila melanogaster)
    - BAR domain proteins recruit dynamin (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        VAChT [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        VAChT [plasma membrane] (Drosophila melanogaster)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Drosophila melanogaster)
      - CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        VAChT [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        VAChT [plasma membrane] (Drosophila melanogaster)
    - Cargo recognition for clathrin-mediated endocytosis (Drosophila melanogaster)
      - AP-2 directly binds some endocytic cargo (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        VAChT [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        VAChT [plasma membrane] (Drosophila melanogaster)
    - Clathrin recruits PIK3C2A (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        VAChT [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        VAChT [plasma membrane] (Drosophila melanogaster)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        VAChT [plasma membrane] (Drosophila melanogaster)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        VAChT [plasma membrane] (Drosophila melanogaster)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        VAChT [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        VAChT [plasma membrane] (Drosophila melanogaster)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        VAChT [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        VAChT [plasma membrane] (Drosophila melanogaster)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        VAChT [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2:cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 cargo [plasma membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
        
        VAChT [plasma membrane] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:O17444

Gene Names

VAChT

Reference Genes

BioGPS Gene:42795 VAChT

ENSEMBL:FBgn0270928

FlyBase:FBgn0270928

KEGG:dme:Dmel_CG32848 VAChT

Monarch:42795 VAChT

NCBI Gene:42795 VAChT

UCSC:O17444 VAChT

Reference Transcript

RefSeq:NM_057790.5 VAChT

Other Identifiers

1636264_at

42795

GO:0005215

GO:0005277

GO:0006836

GO:0007268

GO:0015695

GO:0016020

GO:0022857

GO:0023052

GO:0030121

GO:0030122

GO:0042908

GO:0042910

GO:0043195

GO:0055085

GO:1901374

Participates

as a member of

AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)

as an output of

Release of acetylcholine at the synapse (Drosophila melanogaster)

Other forms of this molecule

VAChT [clathrin-coated endocytic vesicle membrane]

VAChT [clathrin-sculpted acetylcholine transport vesicle membrane]

Inferred From

SLC18A3 [plasma membrane] (Homo sapiens)

Cross References

ENSEMBL

FBpp0083086, FBgn0270928, FBtr0083671

FlyBase

FBgn0270928

PRO

O17444

GlyGen

O17444

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