Reactome | Hr96 [nucleoplasm]

Hr96 [nucleoplasm]

Stable Identifier

R-DME-375500-2

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

NR1H2, Q24143

Locations in the PathwayBrowser

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Metabolism of proteins (Drosophila melanogaster)

- Post-translational protein modification (Drosophila melanogaster)
  - SUMOylation (Drosophila melanogaster)
    - SUMO E3 ligases SUMOylate target proteins (Drosophila melanogaster)
      - SUMOylation of intracellular receptors (Drosophila melanogaster)
        
        HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Drosophila melanogaster)
        
        NR1H2:hydroxycholesterol [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of NR1H2 [nucleoplasm] (Drosophila melanogaster)
        
        Hr96 [nucleoplasm] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Signaling by Nuclear Receptors (Drosophila melanogaster)
  - NR1H2 and NR1H3-mediated signaling (Drosophila melanogaster)
    - NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis (Drosophila melanogaster)
      - Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene (Drosophila melanogaster)
        
        UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of NR1H2 [nucleoplasm] (Drosophila melanogaster)
        
        Hr96 [nucleoplasm] (Drosophila melanogaster)
        
        UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand:NCOR [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of NR1H2 [nucleoplasm] (Drosophila melanogaster)
        
        Hr96 [nucleoplasm] (Drosophila melanogaster)
      - NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Drosophila melanogaster)
        
        UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of NR1H2 [nucleoplasm] (Drosophila melanogaster)
        
        Hr96 [nucleoplasm] (Drosophila melanogaster)
        
        UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand:NCOA1 [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of NR1H2 [nucleoplasm] (Drosophila melanogaster)
        
        Hr96 [nucleoplasm] (Drosophila melanogaster)
      - Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Drosophila melanogaster)
        
        UGT1A3 gene:NR1H2,3:RXR:NCOR [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of NR1H2 [nucleoplasm] (Drosophila melanogaster)
        
        Hr96 [nucleoplasm] (Drosophila melanogaster)
        
        UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand:NCOR [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of NR1H2 [nucleoplasm] (Drosophila melanogaster)
        
        Hr96 [nucleoplasm] (Drosophila melanogaster)
    - NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux (Drosophila melanogaster)
      - Co-repressor complex dissociates from the transcription unit of the ABCA1 gene (Drosophila melanogaster)
        
        ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of NR1H2 [nucleoplasm] (Drosophila melanogaster)
        
        Hr96 [nucleoplasm] (Drosophila melanogaster)
        
        ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands:NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of NR1H2 [nucleoplasm] (Drosophila melanogaster)
        
        Hr96 [nucleoplasm] (Drosophila melanogaster)
      - NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Drosophila melanogaster)
        
        ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of NR1H2 [nucleoplasm] (Drosophila melanogaster)
        
        Hr96 [nucleoplasm] (Drosophila melanogaster)
        
        NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Drosophila melanogaster)
        
        ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of NR1H2 [nucleoplasm] (Drosophila melanogaster)
        
        Hr96 [nucleoplasm] (Drosophila melanogaster)
      - NCOA1 recruits EP300 to the ABCA1 promoter (Drosophila melanogaster)
        
        EP300:NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Drosophila melanogaster)
        
        NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Drosophila melanogaster)
        
        ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of NR1H2 [nucleoplasm] (Drosophila melanogaster)
        
        Hr96 [nucleoplasm] (Drosophila melanogaster)
        
        NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Drosophila melanogaster)
        
        ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of NR1H2 [nucleoplasm] (Drosophila melanogaster)
        
        Hr96 [nucleoplasm] (Drosophila melanogaster)
      - Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Drosophila melanogaster)
        
        ABCA1gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of NR1H2 [nucleoplasm] (Drosophila melanogaster)
        
        Hr96 [nucleoplasm] (Drosophila melanogaster)
        
        ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands:NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2,3:RXR [nucleoplasm] (Drosophila melanogaster)
        
        NR1H2:RXRA [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of NR1H2 [nucleoplasm] (Drosophila melanogaster)
        
        Hr96 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q24143

Gene Names

Hr96

Reference Genes

BioGPS Gene:42993 Hr96

CTD Gene:42993 Hr96

ENSEMBL:FBgn0015240

Flybase:FBgn0015240

KEGG Gene (Drosophila melanogaster):Dmel_CG11783 Hr96

Monarch:42993 Hr96

NCBI Gene:42993 Hr96

Reference Transcript

RefSeq:NM_079769.3 Hr96

Other Identifiers

152580_at

1639398_at

42993

GO:0000122

GO:0000976

GO:0000977

GO:0000981

GO:0003674

GO:0003677

GO:0003700

GO:0004879

GO:0005575

GO:0005622

GO:0005634

GO:0005975

GO:0006091

GO:0006355

GO:0006357

GO:0006629

GO:0006950

GO:0007165

GO:0007275

GO:0008134

GO:0008150

GO:0008270

GO:0009058

GO:0030154

GO:0030374

GO:0030522

GO:0032991

GO:0034641

GO:0038023

GO:0042025

GO:0042592

GO:0042594

GO:0042632

GO:0043167

GO:0043226

GO:0043565

GO:0044281

GO:0045944

GO:0046872

GO:0048856

GO:0055088

GO:0070328

GO:0070873

GO:0090575

Participant Of

hasMember

Homologues of NR1H2 [nucleoplasm]

Other forms of this molecule

Hr96 [cytosol]

Hr96 [nucleoplasm]

Inferred From

NR1H2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_524493.1

Flybase

FBgn0015240

PRO

Q24143

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