HPO dimer binds to SAV

Stable Identifier
R-DME-390011
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
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HPO dimer binds to SAV
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Hippo (HPO) kinase homodimer associates with the scaffolding protein Salvador (SAV). The C-terminal SARAH (Salvador/Rassf/Hippo) domains of HPO homodimer bind to the N-terminal SARAH domian of SAV.
Literature References
PubMed ID Title Journal Year
14561774 The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis

Jiang, J, Jia, J, Trinko, R, Zhang, W, Wang, B

Genes Dev 2003
12941274 The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis

Harvey, KF, Pfleger, CM, Hariharan, IK

Cell 2003
14502295 The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila

Tapon, N, Léopold, P, Pantalacci, S

Nat Cell Biol 2003
12941273 hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts

Wu, S, Pan, D, Dong, J, Huang, J

Cell 2003
14502294 Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway

Halder, G, Nolo, R, Udan, RS, Kango-Singh, M, Tao, C

Nat Cell Biol 2003
Participants
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Output
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Authored
Williams, MG  (2009-01-23)
Reviewed
Irvine, KD  (2009-11-25)
Created
Williams, MG  (2009-01-23)
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