HPO dimer autophosphorylates

Stable Identifier
R-DME-390035
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
ReviewStatus
5/5
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The Hippo (HPO) serine/threonine kinase homodimer autophosphorylates on unknown residues and is activated. The scaffolding protein Salvador (SAV) appears to modestly increase the ability of HPO to autophosphorylate.
Literature References
PubMed ID Title Journal Year
12223493 Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation

Reszka, AA, Rodan, GA, Glantschnig, H

J Biol Chem 2002
14502295 The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila

Tapon, N, LĂ©opold, P, Pantalacci, S

Nat Cell Biol 2003
17347649 Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila

Lai, ZC, Wei, X, Shimizu, T

EMBO J 2007
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of MATS:HPO dimer:SAV:WTS [cytosol]

Authored
Reviewed
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