14-3-3 dimer binds to phosphorylated YKI

Stable Identifier
R-DME-390078
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
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14-3-3 dimer binds to phosphorylated YKI
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The phosphorylated transcription factor Yorkie (YKI) associates with either one of the two 14-3-3 dimer isoforms (14-3-3epsilon or 14-3-3zeta). This effectively anchors YKI in the cytosol and prevents it entering the nucleus to activate its target genes.
Literature References
PubMed ID Title Journal Year
18256197 In vivo regulation of Yorkie phosphorylation and localization

Oh, H, Irvine, KD

Development 2008
17889654 Elucidation of a universal size-control mechanism in Drosophila and mammals

Wu, S, Comerford, SA, Pan, D, Maitra, A, Anders, RA, Gayyed, MF, Dong, J, Zhang, N, Huang, J, Feldmann, G

Cell 2007
Participants
Input
Output
Participates
as an event of
Authored
Williams, MG  (2009-01-23)
Reviewed
Irvine, KD  (2009-11-25)
Created
Williams, MG  (2009-01-23)
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