Phosphorylated HPO dimer phosphorylates TH

Stable Identifier
R-DME-390120
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
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Phosphorylated HPO dimer phosphorylates TH
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Activated Hippo (HPO) serine/threonine kinase phosphorylates Thread (TH) aka drosophila inhibitor of apoptosis protein 1 (Diap1) at unknown residues. This affects TH's stability.
Literature References
PubMed ID Title Journal Year
12941274 The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis

Harvey, KF, Pfleger, CM, Hariharan, IK

Cell 2003
14502295 The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila

Tapon, N, Léopold, P, Pantalacci, S

Nat Cell Biol 2003
Participants
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of Phospho HPO dimer:Phospho SAV:Phospho (2 sites) WTS:Phospho MATS [cytosol]

Physical Entity
Phospho HPO dimer:Phospho SAV:Phospho (2 sites) WTS:Phospho MATS [cytosol] (Drosophila melanogaster)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Williams, MG  (2009-01-23)
Reviewed
Irvine, KD  (2009-11-25)
Created
Williams, MG  (2009-01-23)
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