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VBC complex [cytosol]
Stable Identifier
R-DME-390483
Type
Complex
Species
Drosophila melanogaster
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to hypoxia (Drosophila melanogaster)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Drosophila melanogaster)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Drosophila melanogaster)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Proteasome proteolyzes ub-HIF-alpha (Drosophila melanogaster)
VBC complex (with or without LIMD1) [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Class I MHC mediated antigen processing & presentation (Drosophila melanogaster)
Antigen processing: Ubiquitination & Proteasome degradation (Drosophila melanogaster)
Interaction of E3 with substrate and E2-Ub complex (Drosophila melanogaster)
Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Polyubiquitination of substrate (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
E3:Ub:substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Release of E3 from polyubiquitinated substrate (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Transfer of Ub from E2 to substrate and release of E2 (Drosophila melanogaster)
Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
E3:Ub:substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Neddylation (Drosophila melanogaster)
26S proteasome degrades HIFalpha (Drosophila melanogaster)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Drosophila melanogaster)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Drosophila melanogaster)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Drosophila melanogaster)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Drosophila melanogaster)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Drosophila melanogaster)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Drosophila melanogaster)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Drosophila melanogaster)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
VBC complex [cytosol] (Drosophila melanogaster)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
EloB [cytosol]
(Drosophila melanogaster)
EloC [cytosol]
(Drosophila melanogaster)
Vhl [cytosol]
(Drosophila melanogaster)
Participates
as a component of
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
RBX1-CUL2-EloB,C-VHL [cytosol] (Drosophila melanogaster)
Inferred From
VBC complex [cytosol]
(Homo sapiens)
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