Reactome | Octalpha2R [plasma membrane]

Octalpha2R [plasma membrane]

Stable Identifier

R-DME-390662

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

plasma membrane

Synonyms

ADRA2C, A0A0B4KHD0

Locations in the PathwayBrowser

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Hemostasis (Drosophila melanogaster)

- Platelet activation, signaling and aggregation (Drosophila melanogaster)
  - Platelet Aggregation (Plug Formation) (Drosophila melanogaster)
    - Adrenaline signalling through Alpha-2 adrenergic receptor (Drosophila melanogaster)
      - ADRA2A,B,C bind ADR,NAd (Drosophila melanogaster)
        
        ADRA2A,B,C [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADRA2C [plasma membrane] (Drosophila melanogaster)
        
        Octalpha2R [plasma membrane] (Drosophila melanogaster)
        
        ADRA2A,B,C:ADR,NAd [plasma membrane] (Drosophila melanogaster)
        
        ADRA2A,B,C [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADRA2C [plasma membrane] (Drosophila melanogaster)
        
        Octalpha2R [plasma membrane] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Signaling by GPCR (Drosophila melanogaster)
  - GPCR downstream signalling (Drosophila melanogaster)
    - G alpha (i) signalling events (Drosophila melanogaster)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Drosophila melanogaster)
        
        ADRA2A,B,C:ADR,NAd [plasma membrane] (Drosophila melanogaster)
        
        ADRA2A,B,C [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADRA2C [plasma membrane] (Drosophila melanogaster)
        
        Octalpha2R [plasma membrane] (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Drosophila melanogaster)
        
        ADRA2A,B,C:ADR,NAd [plasma membrane] (Drosophila melanogaster)
        
        ADRA2A,B,C [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADRA2C [plasma membrane] (Drosophila melanogaster)
        
        Octalpha2R [plasma membrane] (Drosophila melanogaster)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Drosophila melanogaster)
        
        ADRA2A,B,C:ADR,NAd [plasma membrane] (Drosophila melanogaster)
        
        ADRA2A,B,C [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADRA2C [plasma membrane] (Drosophila melanogaster)
        
        Octalpha2R [plasma membrane] (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Drosophila melanogaster)
        
        ADRA2A,B,C:ADR,NAd [plasma membrane] (Drosophila melanogaster)
        
        ADRA2A,B,C [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADRA2C [plasma membrane] (Drosophila melanogaster)
        
        Octalpha2R [plasma membrane] (Drosophila melanogaster)
      - The Ligand:GPCR:Gi complex dissociates (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Drosophila melanogaster)
        
        ADRA2A,B,C:ADR,NAd [plasma membrane] (Drosophila melanogaster)
        
        ADRA2A,B,C [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADRA2C [plasma membrane] (Drosophila melanogaster)
        
        Octalpha2R [plasma membrane] (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Drosophila melanogaster)
        
        ADRA2A,B,C:ADR,NAd [plasma membrane] (Drosophila melanogaster)
        
        ADRA2A,B,C [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADRA2C [plasma membrane] (Drosophila melanogaster)
        
        Octalpha2R [plasma membrane] (Drosophila melanogaster)
    - G alpha (z) signalling events (Drosophila melanogaster)
      - Liganded Gz-activating GPCR acts as a GEF for Gz (Drosophila melanogaster)
        
        ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] (Drosophila melanogaster)
        
        ADRA2A,B,C:ADR,NAd [plasma membrane] (Drosophila melanogaster)
        
        ADRA2A,B,C [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADRA2C [plasma membrane] (Drosophila melanogaster)
        
        Octalpha2R [plasma membrane] (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Drosophila melanogaster)
        
        ADRA2A,B,C:ADR,NAd [plasma membrane] (Drosophila melanogaster)
        
        ADRA2A,B,C [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADRA2C [plasma membrane] (Drosophila melanogaster)
        
        Octalpha2R [plasma membrane] (Drosophila melanogaster)
  - GPCR ligand binding (Drosophila melanogaster)
    - Class A/1 (Rhodopsin-like receptors) (Drosophila melanogaster)
      - Amine ligand-binding receptors (Drosophila melanogaster)
        
        Adrenoceptors (Drosophila melanogaster)
        
        ADRA2A,B,C bind ADR,NAd (Drosophila melanogaster)
        
        ADRA2A,B,C [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADRA2C [plasma membrane] (Drosophila melanogaster)
        
        Octalpha2R [plasma membrane] (Drosophila melanogaster)
        
        ADRA2A,B,C:ADR,NAd [plasma membrane] (Drosophila melanogaster)
        
        ADRA2A,B,C [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADRA2C [plasma membrane] (Drosophila melanogaster)
        
        Octalpha2R [plasma membrane] (Drosophila melanogaster)
        
        α2-agonists bind ADRA2A,B,C (Drosophila melanogaster)
        
        ADRA2A,B,C [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADRA2C [plasma membrane] (Drosophila melanogaster)
        
        Octalpha2R [plasma membrane] (Drosophila melanogaster)
        
        α2-agonists:ADRA2A,B,C [plasma membrane] (Drosophila melanogaster)
        
        ADRA2A,B,C [plasma membrane] (Drosophila melanogaster)
        
        Homologues of ADRA2C [plasma membrane] (Drosophila melanogaster)
        
        Octalpha2R [plasma membrane] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:A0A0B4KHD0

Gene Names

Octalpha2R

Reference Genes

BioGPS Gene:42258 Octalpha2R

ENSEMBL:FBgn0038653

Flybase:FBgn0038653

Monarch:42258 Octalpha2R

NCBI Gene:42258 Octalpha2R

Reference Transcript

RefSeq:NM_001275786.2 Octalpha2R

Other Identifiers

150163_at

1633580_at

42258

GO:0004930

GO:0004989

GO:0005886

GO:0007165

GO:0007186

GO:0007193

GO:0008227

GO:0016020

GO:0023052

GO:0032795

GO:0060089

GO:0071880

Participates

as a member of

Homologues of ADRA2C [plasma membrane] (Drosophila melanogaster)

Other forms of this molecule

Octalpha2R [plasma membrane]

Inferred From

ADRA2C [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001262715.1

Flybase

FBgn0038653

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