Reactome | Me2K-10-H3F3A [nucleoplasm]

Me2K-10-H3F3A [nucleoplasm]

Stable Identifier

R-DME-427324

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

C0HL66

Locations in the PathwayBrowser

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Cellular responses to external stimuli (Drosophila melanogaster)

- Cellular responses to stress (Drosophila melanogaster)
  - Cellular Senescence (Drosophila melanogaster)
    - Senescence-Associated Secretory Phenotype (SASP) (Drosophila melanogaster)
      - EHMT1:EHMT2 methylates IL6 promoter (Drosophila melanogaster)
        
        IL6 gene:Nucleosome-H3K9Me2 [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
      - EHMT1:EHMT2 methylates IL8 promoter (Drosophila melanogaster)
        
        IL8 gene:Nucleosome-H3K9Me2 [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)

Gene expression (Transcription) (Drosophila melanogaster)

- Epigenetic regulation of gene expression (Drosophila melanogaster)
  - Negative epigenetic regulation of rRNA expression (Drosophila melanogaster)
    - SIRT1 negatively regulates rRNA expression (Drosophila melanogaster)
      - Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Drosophila melanogaster)
        
        Chromatin (H3K9me2) [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        eNoSC [nucleoplasm] (Drosophila melanogaster)
        
        Chromatin (H3K9me2) [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
      - eNoSC deacetylates histone H3 (Drosophila melanogaster)
        
        eNoSC [nucleoplasm] (Drosophila melanogaster)
        
        Chromatin (H3K9me2) [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
      - eNoSC dimethylates histone H3 at lysine-9 (Drosophila melanogaster)
        
        Chromatin (H3K9me2) [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        eNoSC [nucleoplasm] (Drosophila melanogaster)
        
        Chromatin (H3K9me2) [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
- RNA Polymerase I Transcription (Drosophila melanogaster)
  - RNA Polymerase I Promoter Clearance (Drosophila melanogaster)
    - RNA Polymerase I Promoter Escape (Drosophila melanogaster)
      - Elongation of pre-rRNA transcript (Drosophila melanogaster)
        
        Chromatin (H3K9me2):CBX3 [nucleoplasm] (Drosophila melanogaster)
        
        Chromatin (H3K9me2) [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Signaling by Nuclear Receptors (Drosophila melanogaster)
  - ESR-mediated signaling (Drosophila melanogaster)
    - Estrogen-dependent gene expression (Drosophila melanogaster)
      - KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Drosophila melanogaster)
        
        MYC gene, BCL2 gene: H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG:KDM1A [nucleoplasm] (Drosophila melanogaster)
        
        MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
      - KDM1A is recruited to MYC and BCL2 genes (Drosophila melanogaster)
        
        MYC gene, BCL2 gene: H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG:KDM1A [nucleoplasm] (Drosophila melanogaster)
        
        MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Drosophila melanogaster)
        
        Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Drosophila melanogaster)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)
        
        Me2K-10-H3F3A [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:C0HL66

Reference Genes

BioGPS Gene:31848

BioGPS Gene:33736

CTD Gene:31848

dbSNP Gene:31848

dbSNP Gene:33736

ENSEMBL:FBgn0014857

Flybase:FBgn0014857

KEGG Gene (Drosophila melanogaster):Dmel_CG5825

KEGG Gene (Drosophila melanogaster):Dmel_CG8989

Monarch:31848

Monarch:33736

NCBI Gene:31848

NCBI Gene:33736

Reference Transcript

Other Identifiers

142668_at

143766_i_at

143767_r_at

1623222_s_at

1627685_a_at

7227.FBpp0305663

AAF46452.1

AAF52213.1

AAN09245.1

AAN10526.2

AAO41645.1

AGB92618.1

AGB95217.1

AY071057

AY118325

AY119629

CAA57077.1

CAA57080.1

EntrezGene:31848

EntrezGene:33736

FBgn0004828

FBgn0014857

FBpp0071280

FBpp0071281

FBpp0071282

FBpp0078649

FBpp0305716

FBpp0305717

FBpp0309302

FBtr0071345

FBtr0071346

FBtr0071347

FBtr0079010

FBtr0333536

FBtr0333537

FBtr0340343

GO:0000003

GO:0000786

GO:0003674

GO:0003677

GO:0005198

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005694

GO:0005700

GO:0006334

GO:0006336

GO:0007049

GO:0007140

GO:0008150

GO:0022607

GO:0030527

GO:0031492

GO:0032991

GO:0043226

GO:0046982

GO:0051276

GO:0065003

IPR000164

IPR007125

IPR009072

KX531337

KX531588

NM_001272445.2

NM_001273153.1

NM_078540.5

NM_078755.3

NM_164624.3

NM_167180.4

NM_176719.1

NP_001259374.1

NP_001260082.1

NP_511095.1

NP_523479.1

NP_723056.2

NP_727314.1

NP_788892.1

PF00125

PR00622

SM00428

UPI00000007B0

X53822

X82257

Participant Of

hasMember

Homologues of Me2K-10-H3F3A [nucleoplasm]

Other forms of this molecule

MeK-H3F3A [nucleoplasm]

2xAcK-H3F3A [nucleoplasm]

AcK10-H3F3A [nucleoplasm]

Me2K5-H3F3A [nucleoplasm]

Me3K-28-H3F3A [nucleoplasm]

H3F3A [nucleoplasm]

Me3K5-H3F3A [nucleoplasm]

phospho-p-T12,Me3K-10-H3F3A [nucleoplasm]

Me3K-10-H3F3A [nucleoplasm]

p-T12, Me2K-10-H3F3A [nucleoplasm]

phospho-p-T12,MeK-H3F3A [nucleoplasm]

phospho-p-T12-H3F3A [nucleoplasm]

Inferred From

Me2K-10-H3F3A [nucleoplasm] (Homo sapiens)

Modified Residues

Name

N6,N6-dimethyl-L-lysine at 10 (in Homo sapiens)

Coordinate

PsiMod Name

N6,N6-dimethyl-L-lysine [MOD:00084]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6,N6-dimethyl-L-lysine.

Cross References

RefSeq

NP_727314.1, NP_788892.1, NP_001259374.1, NP_723056.2, NP_511095.1, NP_001260082.1, NP_523479.1

Flybase

FBgn0014857

PRO

C0HL66