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RAC1_DROME [cytosol]
Stable Identifier
R-DME-428467
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
Ras-related protein Rac1, Rac1
Locations in the PathwayBrowser
Expand all
Developmental Biology (Drosophila melanogaster)
Nervous system development (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
EPH-Ephrin signaling (Drosophila melanogaster)
EPH-ephrin mediated repulsion of cells (Drosophila melanogaster)
TIAM1 exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)
Rac1:GDP [cytosol] (Drosophila melanogaster)
RAC1_DROME [cytosol] (Drosophila melanogaster)
VAV exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)
Rac1:GDP [cytosol] (Drosophila melanogaster)
RAC1_DROME [cytosol] (Drosophila melanogaster)
EPHB-mediated forward signaling (Drosophila melanogaster)
p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)
Rac1:GDP [cytosol] (Drosophila melanogaster)
RAC1_DROME [cytosol] (Drosophila melanogaster)
L1CAM interactions (Drosophila melanogaster)
Signal transduction by L1 (Drosophila melanogaster)
Activation of Rac1 by VAV2 (Drosophila melanogaster)
Rac1:GDP [cytosol] (Drosophila melanogaster)
RAC1_DROME [cytosol] (Drosophila melanogaster)
Netrin-1 signaling (Drosophila melanogaster)
DCC mediated attractive signaling (Drosophila melanogaster)
Activation of Rac1 (Drosophila melanogaster)
Rac1:GDP [cytosol] (Drosophila melanogaster)
RAC1_DROME [cytosol] (Drosophila melanogaster)
Hemostasis (Drosophila melanogaster)
Factors involved in megakaryocyte development and platelet production (Drosophila melanogaster)
DOCKs bind to RhoGEFs (Drosophila melanogaster)
DOCK-GEFs:RAC1, CDC42 [cytosol] (Drosophila melanogaster)
RAC1, CDC42 [cytosol] (Drosophila melanogaster)
RAC1_DROME [cytosol] (Drosophila melanogaster)
RAC1, CDC42 [cytosol] (Drosophila melanogaster)
RAC1_DROME [cytosol] (Drosophila melanogaster)
Platelet activation, signaling and aggregation (Drosophila melanogaster)
GPVI-mediated activation cascade (Drosophila melanogaster)
VAV1 is a GEF for Rho/Rac family GTPases (Drosophila melanogaster)
VAV1 Rho/Rac effectors:GDP [cytosol] (Drosophila melanogaster)
VAV1 effectors [cytosol] (Drosophila melanogaster)
Homologues of RAC2 [cytosol] (Drosophila melanogaster)
RAC1_DROME [cytosol] (Drosophila melanogaster)
RAC1_DROME [cytosol] (Drosophila melanogaster)
VAV1 Rho/Rac effectors:GTP [cytosol] (Drosophila melanogaster)
VAV1 effectors [cytosol] (Drosophila melanogaster)
Homologues of RAC2 [cytosol] (Drosophila melanogaster)
RAC1_DROME [cytosol] (Drosophila melanogaster)
RAC1_DROME [cytosol] (Drosophila melanogaster)
VAV2 is a GEF for Rho/Rac family kinases (Drosophila melanogaster)
VAV2 Rho/Rac effectors:GDP [cytosol] (Drosophila melanogaster)
VAV2 effectors [cytosol] (Drosophila melanogaster)
RAC1_DROME [cytosol] (Drosophila melanogaster)
VAV2 Rho/Rac effectors:GTP [cytosol] (Drosophila melanogaster)
VAV2 effectors [cytosol] (Drosophila melanogaster)
RAC1_DROME [cytosol] (Drosophila melanogaster)
VAV3 is a GEF for Rho/Rac family kinases (Drosophila melanogaster)
VAV3 Rho/Rac effectors:GDP [cytosol] (Drosophila melanogaster)
VAV3 effectors [cytosol] (Drosophila melanogaster)
RAC1_DROME [cytosol] (Drosophila melanogaster)
VAV3 Rho/Rac effectors:GTP [cytosol] (Drosophila melanogaster)
VAV3 effectors [cytosol] (Drosophila melanogaster)
RAC1_DROME [cytosol] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
DAP12 interactions (Drosophila melanogaster)
DAP12 signaling (Drosophila melanogaster)
Activation of RAC1 by VAV2/3 (Drosophila melanogaster)
Rac1:GDP [cytosol] (Drosophila melanogaster)
RAC1_DROME [cytosol] (Drosophila melanogaster)
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
FCERI mediated MAPK activation (Drosophila melanogaster)
Activation of RAC1 by VAV (Drosophila melanogaster)
Rac1:GDP [cytosol] (Drosophila melanogaster)
RAC1_DROME [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by SCF-KIT (Drosophila melanogaster)
Activation of RAC1 (Drosophila melanogaster)
Rac1:GDP [cytosol] (Drosophila melanogaster)
RAC1_DROME [cytosol] (Drosophila melanogaster)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Drosophila melanogaster)
Signaling by Rho GTPases (Drosophila melanogaster)
RHO GTPase cycle (Drosophila melanogaster)
RAC1 GTPase cycle (Drosophila melanogaster)
RAC1 GDIs block activation of RAC1 (Drosophila melanogaster)
RAC1:GDP:RAC1 GDIs [cytosol] (Drosophila melanogaster)
Rac1:GDP [cytosol] (Drosophila melanogaster)
RAC1_DROME [cytosol] (Drosophila melanogaster)
RAC2 GTPase cycle (Drosophila melanogaster)
RAC2 GDIs block activation of RAC2 (Drosophila melanogaster)
ARHGDIA:RAC2:GDP [cytosol] (Drosophila melanogaster)
RAC2:GDP [cytosol] (Drosophila melanogaster)
Homologues of RAC2 [cytosol] (Drosophila melanogaster)
RAC1_DROME [cytosol] (Drosophila melanogaster)
RAC3 GTPase cycle (Drosophila melanogaster)
RAC3 GDIs block activation of RAC3 (Drosophila melanogaster)
RAC3:GDP:RAC3 GDIs [cytosol] (Drosophila melanogaster)
Rac1:GDP [cytosol] (Drosophila melanogaster)
RAC1_DROME [cytosol] (Drosophila melanogaster)
Signaling by WNT (Drosophila melanogaster)
Beta-catenin independent WNT signaling (Drosophila melanogaster)
PCP/CE pathway (Drosophila melanogaster)
ppDVL recruits RAC (Drosophila melanogaster)
RAC:GTP [cytosol] (Drosophila melanogaster)
RAC [cytosol] (Drosophila melanogaster)
Homologues of RAC2 [cytosol] (Drosophila melanogaster)
RAC1_DROME [cytosol] (Drosophila melanogaster)
RAC1_DROME [cytosol] (Drosophila melanogaster)
pp-DVL:RAC:GTP [plasma membrane] (Drosophila melanogaster)
RAC:GTP [cytosol] (Drosophila melanogaster)
RAC [cytosol] (Drosophila melanogaster)
Homologues of RAC2 [cytosol] (Drosophila melanogaster)
RAC1_DROME [cytosol] (Drosophila melanogaster)
RAC1_DROME [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P40792 Rac1
Gene Names
Rac1, RacA, CG2248
Chain
chain:1-189, propeptide:190-192
Reference Genes
BioGPS Gene:38146 Rac1
KEGG:dme:Dmel_CG2248 Rac1
Monarch:38146 Rac1
NCBI Gene:38146 Rac1
UCSC:P40792 Rac1
Reference Transcript
RefSeq:NM_001274318.1 Rac1
RefSeq:NM_057602.4 Rac1
Other Identifiers
143597_at
1632279_at
38146
GO:0000902
GO:0001667
GO:0001726
GO:0001954
GO:0002376
GO:0002433
GO:0003006
GO:0003014
GO:0003824
GO:0003924
GO:0005515
GO:0005525
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005938
GO:0006909
GO:0006911
GO:0007010
GO:0007015
GO:0007163
GO:0007165
GO:0007254
GO:0007264
GO:0007298
GO:0007390
GO:0007391
GO:0007394
GO:0007395
GO:0007411
GO:0007413
GO:0007419
GO:0007422
GO:0007424
GO:0007426
GO:0007435
GO:0007516
GO:0007520
GO:0007613
GO:0008045
GO:0008078
GO:0008258
GO:0008347
GO:0008360
GO:0009611
GO:0010593
GO:0016028
GO:0016192
GO:0016199
GO:0016203
GO:0016358
GO:0016787
GO:0019901
GO:0022412
GO:0022414
GO:0030030
GO:0030032
GO:0030036
GO:0030295
GO:0030707
GO:0030865
GO:0030866
GO:0031175
GO:0031410
GO:0031532
GO:0032147
GO:0032794
GO:0032956
GO:0035006
GO:0035010
GO:0035011
GO:0035099
GO:0035212
GO:0035320
GO:0036090
GO:0042052
GO:0042995
GO:0043226
GO:0043652
GO:0045773
GO:0046330
GO:0046664
GO:0046843
GO:0048010
GO:0048615
GO:0048675
GO:0048812
GO:0048814
GO:0048856
GO:0048870
GO:0050770
GO:0050807
GO:0050877
GO:0050975
GO:0051017
GO:0051450
GO:0051491
GO:0051963
GO:0055001
GO:0060326
GO:0060429
GO:0061024
GO:0071902
GO:0071907
GO:0090303
GO:0097206
GO:0098542
GO:0098772
GO:0110125
GO:1902669
GO:1903391
GO:1903688
GO:1904059
Participates
as a member of
VAV1 effectors [cytosol] (Drosophila melanogaster)
RAC1, CDC42 [cytosol] (Drosophila melanogaster)
RAC [cytosol] (Drosophila melanogaster)
Homologues of RAC2 [cytosol] (Drosophila melanogaster)
VAV3 effectors [cytosol] (Drosophila melanogaster)
as a component of
Rac1:GTP [cytosol] (Drosophila melanogaster)
Rac1:GDP [cytosol] (Drosophila melanogaster)
as a candidate of
VAV2 effectors [cytosol] (Drosophila melanogaster)
Other forms of this molecule
RAC2 [mitochondrial outer membrane]
RAC1 [endoplasmic reticulum membrane]
RHOG [endoplasmic reticulum membrane]
RAC2 [phagocytic vesicle membrane]
RAC1 [secretory granule membrane]
RHOG [secretory granule membrane]
RAC1 [ficolin-1-rich granule membrane]
GGC-PalmC-RAC1 [plasma membrane]
RHOG [cytosol]
RHOG [plasma membrane]
RAC1 [plasma membrane]
Inferred From
RAC2 [cytosol]
(Homo sapiens)
RAC3 [cytosol]
(Homo sapiens)
RAC1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001261247.1
,
NP_476950.1
ENSEMBL
FBtr0331868
,
FBpp0072614
,
FBpp0304252
,
FBtr0072730
FlyBase
FBgn0010333
PRO
P40792
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9VI13 Pak
12
phospho-p-S141,T402-PAK2 [cytosol]
(R-DME-399824-2)
phospho-p-S144,T423-PAK1 [cytosol]
(R-DME-399819)
PAK2 [cytosol]
(R-DME-211604-2)
PAK1 [cytosol]
(R-DME-162629)
PAK3 [cytosol]
(R-DME-428457-2)
phospho-p-S154,T436-PAK3 [cytosol]
(R-DME-5357471-2)
phospho-p-Y130,S141,T402-PAK2 [cytosol]
(R-DME-5218705-2)
Pak [cytosol]
(R-DME-428468)
phospho-p-S141,T402-PAK2 [plasma membrane]
(R-DME-5096524-2)
phospho-p-S144,T423-PAK1 [plasma membrane]
(R-DME-3928472)
phospho-p-S154,T436-PAK3 [plasma membrane]
(R-DME-3928479-2)
PAK1 [plasma membrane]
(R-DME-3928409)
0.766
5
UniProt:Q9V4A7
3
phospho-PlexB [plasma membrane]
(R-DME-419609)
PlexB [plasma membrane]
(R-DME-3008951)
PlexB [plasma membrane]
(R-DME-416675)
0.502
2
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