Inactivation of Rac1

Stable Identifier
R-DME-428520
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Inactivation of Rac1
In Drosophila, Vilse binds directly to the intracellular domains of the Robo1 receptor and promotes the hydrolysis of GTP bound to Rac1, thus converting Rac1 to the inactive, GDP-bound form (Lundstrom et al. 2004, Hu et al. 2005).
Literature References
PubMed ID Title Journal Year
15342493 Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons

Lundström, A, Hemphälä, J, Keleman, K, Steneberg, P, Gallio, M, Aspenström, P, Falileeva, L, Samakovlis, C, Englund, C, Dickson, BJ

Genes Dev 2004
15755809 Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion

Li, M, Bashaw, GJ, Goodman, CS, Lai, EC, McEwen, J, Hu, H, Labrador, JP

Proc Natl Acad Sci U S A 2005
Participants
Input
Output
Catalyst Activity

GTPase activator activity of Robo:Slit:Vilse [plasma membrane]

Physical Entity
Robo:Slit:Vilse [plasma membrane] (Drosophila melanogaster)
Activity
GTPase activator activity (GO:0005096)
Orthologous Events
Inactivation of RAC1 (Homo sapiens)
Authored
Garapati, P V  (2008-09-05)
Reviewed
Jaworski, A  (2017-07-31)
Kidd, T  (2009-08-18)
Created
Garapati, P V  (2009-07-06)
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