DCC interaction with Robo-1

Stable Identifier
R-DME-428953
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
DCC interaction with Robo-1
Dcc and Robo-1 heterodimerize via conserved sequence elements in their cytoplasmic domains, namely CC1 (conserved cytoplasmic region1) in Robo-1 and P3 in Dcc. The formation of this complex is dependent on the previous interaction between Robo and its ligand (Slit). This physical interaction between Robo:Slit and Dcc silences the attractive effect of Netrin:Dcc and regulates the midline crossing of axons.
From the analysis of multiple double mutant combinations of the Robo:Slit and Netrin:Dcc receptor-ligand pairs, it was deduced that Robo repulsion on its own is sufficient to prevent commissural axons from re-crossing the midline, and that Netrin:Dcc is not the only source of attraction at the midline (Garbe and Bashaw 2007).
Literature References
Participants
Orthologous Events
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