PDP1 replaces VRI as binder to Clk and cry genes

Stable Identifier
R-DME-432381
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
ReviewStatus
5/5
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PAR domain protein-1 (PDP1) levels reach their peak between mid to late night. Vrille (VRI) levels decline during this time due to TIM:PER:DCO mediated repression of Clock (CLK) driven vri transcription. The decreasing ratio of VRI/PDP1 levels favours binding of PDP1 over VRI to the V/P boxes resulting in activation of Clk and cry transcription.
Literature References
PubMed ID Title Journal Year
19726650 An isoform-specific mutant reveals a role of PDP1 epsilon in the circadian oscillator

Chen, D, Sehgal, A, Sowcik, M, Zheng, X, Smith, CJ, Koh, K, Wu, MN

J Neurosci 2009
12546820 VRILLE feeds back to control circadian transcription of Clock in the Drosophila circadian oscillator

Ng, FS, Glossop, NR, Hardin, PE, Zheng, H, Dudek, SM, Houl, JH

Neuron 2003
12581523 vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock

Reddy, KL, Glossop, NR, Hardin, PE, Lin, MC, Young, MW, Buchsbaum, AM, Storti, RV, Blau, J, Cyran, SA

Cell 2003
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