CLK:CYC heterodimer binds to per, tim, vri, and Pdp1 genes

Stable Identifier
R-DME-432436
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
ReviewStatus
5/5
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At midday, the Clock (CLK):Cycle (CYC) heteodimer binds the E-box regulatory elements of the target genes, per, tim, vri, and Pdp1. Transcription of these genes is now activated.
Literature References
PubMed ID Title Journal Year
10612401 Cycling vrille expression is required for a functional Drosophila clock

Young, MW, Blau, J

Cell 1999
16543224 PER-dependent rhythms in CLK phosphorylation and E-box binding regulate circadian transcription

Dauwalder, B, Hardin, PE, Zheng, H, Houl, JH, Yu, W

Genes Dev 2006
12546820 VRILLE feeds back to control circadian transcription of Clock in the Drosophila circadian oscillator

Ng, FS, Glossop, NR, Hardin, PE, Zheng, H, Dudek, SM, Houl, JH

Neuron 2003
12581523 vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock

Reddy, KL, Glossop, NR, Hardin, PE, Lin, MC, Young, MW, Buchsbaum, AM, Storti, RV, Blau, J, Cyran, SA

Cell 2003
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