Phosphorylated TIM:PER heterodimer dissociate

Stable Identifier
R-DME-432464
Type
Reaction [dissociation]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
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Phosphorylated TIM:PER heterodimer dissociate
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The phosphorylation of Timeless (TIM) and Period (PER) by casein kinase II (CK2) appears to be the trigger for their nuclear entry. However, before this occurs, phosphorylated TIM dissociates from the PER:Discs Overgrown (DCO) complex.
Literature References
PubMed ID Title Journal Year
16410523 PER-TIM interactions in living Drosophila cells: an interval timer for the circadian clock

Saez, L, Young, MW, Meyer, P

Science 2006
12122057 Sequential nuclear accumulation of the clock proteins period and timeless in the pacemaker neurons of Drosophila melanogaster

Truman, JW, Rosbash, M, Shafer, OT

J Neurosci 2002
12944510 Novel insights into the regulation of the timeless protein

Ashmore, LJ, Schotland, P, Silvestre, DW, Sehgal, A, Sathyanarayanan, S, Emerson, MM

J Neurosci 2003
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Authored
Williams, MG  (2009-08-13)
Reviewed
Edery, I  (2010-07-06)
Created
Williams, MG  (2009-08-14)
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