CLK:CYC heterodimer binds to cwo gene and activates transcription

Stable Identifier
R-DME-432520
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
nucleoplasm
ReviewStatus
5/5
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CLK:CYC heterodimer binds to cwo gene and activates transcription
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The Clock (CLK):Cycle (CYC) heteodimer binds the E-box regulatory elements of the target gene, cwo. Transcription of cwo is now activated.
Literature References
PubMed ID Title Journal Year
17555964 Clockwork orange encodes a transcriptional repressor important for circadian-clock amplitude in Drosophila

Allada, R, Keegan, KP, Pradhan, S, Lim, C, Choe, J, Lee, J, McGill, JJ, Chung, BY, Pitman, JL

Curr Biol 2007
18375860 The clockwork orange Drosophila protein functions as both an activator and a repressor of clock gene expression

Lamouroux, A, Papin, C, Richier, B, Rouyer, F, Michard-Vanhée, C

J Biol Rhythms 2008
17578907 Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component

Kadener, S, Nawathean, P, Stoleru, D, Rosbash, M, McDonald, M

Genes Dev 2007
17578908 A functional genomics strategy reveals clockwork orange as a transcriptional regulator in the Drosophila circadian clock

Dauwalder, B, Kasukawa, T, Ueda, R, Houl, J, Ukai-Tadenuma, M, Yamada, RG, Itoh, TQ, Ueda, HR, Hardin, PE, Uno, KD, Takahashi, K, Matsumoto, A, Tanimura, T

Genes Dev 2007
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Authored
Williams, MG  (2009-08-13)
Reviewed
Edery, I  (2010-07-06)
Created
Williams, MG  (2009-08-14)
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