Phosphorylated PER is phosphorylated by CK2

Stable Identifier
R-DME-432590
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Phosphorylated PER is phosphorylated by CK2
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Phosphorylated Period (PER) is phosphorylated on serine residues 149, 151, 153, by casein kinase II (CK2). CK2 phosphorylation appears to be important for subsequent nuclear entry of PER.
Literature References
PubMed ID Title Journal Year
18593878 The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock

Vanselow, JT, Edery, I, Kramer, A, Chiu, JC

Genes Dev 2008
12447397 A role for casein kinase 2alpha in the Drosophila circadian clock

Kilman, VL, Allada, R, Paddock, B, Emery-Le, M, Rosbash, M, Lin, JM, Keegan, K

Nature 2002
16319317 In vivo circadian function of casein kinase 2 phosphorylation sites in Drosophila PERIOD

Allada, R, Lin, JM, Schroeder, A

J Neurosci 2005
12563262 A role for CK2 in the Drosophila circadian oscillator

Raabe, T, Kim, EY, Edery, I, Genova, GK, Akten, B, Jackson, FR, Jauch, E

Nat Neurosci 2003
18815259 TIMELESS is an important mediator of CK2 effects on circadian clock function in vivo

Kilman, VL, Allada, R, Lin, JM, Meissner, RA

J Neurosci 2008
14759367 The doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity

Nawathean, P, Rosbash, M

Mol Cell 2004
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of RAS85D:GTP:SRC42A:Phospho CNK:14-3-3epsilon dimer:Phospho PHL:Phospho KSR:14-3-3epsilon dimer:AVE:DSOR1:CK2:PAR-1:PP2A [plasma membrane]

Physical Entity
RAS85D:GTP:SRC42A:Phospho CNK:14-3-3epsilon dimer:Phospho PHL:Phospho KSR:14-3-3epsilon dimer:AVE:DSOR1:CK2:PAR-1:PP2A [plasma membrane] (Drosophila melanogaster)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Williams, MG  (2009-08-13)
Reviewed
Edery, I  (2010-07-06)
Created
Williams, MG  (2009-08-14)
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