Reactome | Phosphorylated TIM transports from the cytosol to the nucleus

Phosphorylated TIM transports from the cytosol to the nucleus

Stable Identifier

R-DME-432642

Type

Reaction [transition]

Species

Drosophila melanogaster

Compartment

nuclear envelope

ReviewStatus

5/5

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Phosphorylated TIM transports from the cytosol to the nucleus

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After the phosphorylated Period (PER):Discs Overgrown (DCO) complex has entered the nucleus, phosphorylated Timeless (TIM) does the same. The time frame between the two events appears to be variable, depending on the type of neuronal clock cell, and can be up to a few hours later. It is currently not known whether casein kinase II (CK2) is bound to PER and/or TIM and whether it travels with either from the cytosol to the nucleus.

Literature References

PubMed ID	Title	Journal	Year
15930393	The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period Saez, L, Young, MW, Buchsbaum, AM, Blau, J, Yiannoulos, G, Cyran, SA	J Neurosci	2005
16410523	PER-TIM interactions in living Drosophila cells: an interval timer for the circadian clock Saez, L, Young, MW, Meyer, P	Science	2006
12122057	Sequential nuclear accumulation of the clock proteins period and timeless in the pacemaker neurons of Drosophila melanogaster Truman, JW, Rosbash, M, Shafer, OT	J Neurosci	2002
12944510	Novel insights into the regulation of the timeless protein Ashmore, LJ, Schotland, P, Silvestre, DW, Sehgal, A, Sathyanarayanan, S, Emerson, MM	J Neurosci	2003