Phosphorylated PER binds to TIM

Stable Identifier
R-DME-432647
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
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Phosphorylated PER binds to TIM
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After dusk, per and tim genes continue to be transcribed and their mRNAs reach peak levels between during the early part of the night. Timeless (TIM) protein is stable in the dark and so begins to accumulate and forms a complex with Period (PER) and Casein kinase 1epsilon orthologue, Discs Overgrown (DCO) aka Double-time (DBT). TIM stabilises PER despite the continuous attentions of casein kinase II (CK2) and DCO. As a result, PER and TIM accumulate to high levels during the middle of the night.
Literature References
PubMed ID Title Journal Year
8600384 A light-entrainment mechanism for the Drosophila circadian clock

Myers, MP, Qian, Z, Rosbash, M, Zeng, H

Nature 1996
8596938 Resetting the Drosophila clock by photic regulation of PER and a PER-TIM complex

Bae, K, Itsukaichi, T, Edery, I, Lee, C, Parikh, V

Science 1996
11430804 Phosphorylation of period is influenced by cycling physical associations of double-time, period, and timeless in the Drosophila clock

Saez, L, Young, MW, Rothenfluh, A, Kloss, B

Neuron 2001
7481773 Isolation of timeless by PER protein interaction: defective interaction between timeless protein and long-period mutant PERL

Myers, MP, Delahaye-Brown, AM, Sehgal, A, Saez, L, Young, MW, Weitz, CJ, Gekakis, N

Science 1995
16410523 PER-TIM interactions in living Drosophila cells: an interval timer for the circadian clock

Saez, L, Young, MW, Meyer, P

Science 2006
8938123 Regulation of nuclear entry of the Drosophila clock proteins period and timeless

Saez, L, Young, MW

Neuron 1996
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Authored
Williams, MG  (2009-08-13)
Reviewed
Edery, I  (2010-07-06)
Created
Williams, MG  (2009-08-14)
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