Stim activation of CRAC

Stable Identifier
R-DME-434702
Type
Reaction
Species
Drosophila melanogaster
Compartment
Summation

Sustained calcium signalling in lymphocytes and platelets requires the uptake of extracellular calcium when intracellular stores are depleted. The process whereby intracellular calcium depletion stimulates calcium uptake is often referred to as Store-operated calcium entry (SOCE). Store depletion is sensed by stromal interaction molecule 1 (STIM1), which then translocates to the plasma membrane and associates with 2 dimers of Orai to form a calcium-release activated calcium (CRAC) channel.

Literature References
Participants
Orthologous Events