Stim activation of CRAC

Stable Identifier
R-DME-434702
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
plasma membrane, endoplasmic reticulum membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Stim activation of CRAC
Sustained calcium signalling in lymphocytes and platelets requires the uptake of extracellular calcium when intracellular stores are depleted. The process whereby intracellular calcium depletion stimulates calcium uptake is often referred to as Store-operated calcium entry (SOCE). Store depletion is sensed by stromal interaction molecule 1 (STIM1), which then translocates to the plasma membrane and associates with 2 dimers of Orai to form a calcium-release activated calcium (CRAC) channel.
Literature References
PubMed ID Title Journal Year
18820677 The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers

Demuro, A, Zhang, SL, Safrina, O, Penna, A, Cahalan, MD, Yeromin, AV, Parker, I

Nature 2008
Participants
Input
Output
Orthologous Events
STIM1 activation of CRAC (Homo sapiens)
Authored
Akkerman, JW  (2009-09-04)
Reviewed
Kunapuli, SP  (2010-06-07)
Created
Jupe, S  (2009-09-02)
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