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phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm]
Stable Identifier
R-DME-450268
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
P49071
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular Senescence (Drosophila melanogaster)
Oxidative Stress Induced Senescence (Drosophila melanogaster)
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Drosophila melanogaster)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Drosophila melanogaster)
Active MAPKAP kinase [nucleoplasm] (Drosophila melanogaster)
phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Signaling by Interleukins (Drosophila melanogaster)
Interleukin-17 signaling (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
activated TAK1 mediates p38 MAPK activation (Drosophila melanogaster)
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Drosophila melanogaster)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Drosophila melanogaster)
Active MAPKAP kinase [nucleoplasm] (Drosophila melanogaster)
phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Drosophila melanogaster)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Drosophila melanogaster)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Drosophila melanogaster)
Active MAPKAP kinase [nucleoplasm] (Drosophila melanogaster)
phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
Toll-like Receptor Cascades (Drosophila melanogaster)
Toll Like Receptor 10 (TLR10) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
activated TAK1 mediates p38 MAPK activation (Drosophila melanogaster)
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Drosophila melanogaster)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Drosophila melanogaster)
Active MAPKAP kinase [nucleoplasm] (Drosophila melanogaster)
phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Drosophila melanogaster)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Drosophila melanogaster)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Drosophila melanogaster)
Active MAPKAP kinase [nucleoplasm] (Drosophila melanogaster)
phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Drosophila melanogaster)
Toll Like Receptor 2 (TLR2) Cascade (Drosophila melanogaster)
Toll Like Receptor TLR1:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
activated TAK1 mediates p38 MAPK activation (Drosophila melanogaster)
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Drosophila melanogaster)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Drosophila melanogaster)
Active MAPKAP kinase [nucleoplasm] (Drosophila melanogaster)
phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Drosophila melanogaster)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Drosophila melanogaster)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Drosophila melanogaster)
Active MAPKAP kinase [nucleoplasm] (Drosophila melanogaster)
phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Drosophila melanogaster)
Toll Like Receptor TLR6:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
activated TAK1 mediates p38 MAPK activation (Drosophila melanogaster)
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Drosophila melanogaster)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Drosophila melanogaster)
Active MAPKAP kinase [nucleoplasm] (Drosophila melanogaster)
phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Drosophila melanogaster)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Drosophila melanogaster)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Drosophila melanogaster)
Active MAPKAP kinase [nucleoplasm] (Drosophila melanogaster)
phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Drosophila melanogaster)
Toll Like Receptor 3 (TLR3) Cascade (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
activated TAK1 mediates p38 MAPK activation (Drosophila melanogaster)
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Drosophila melanogaster)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Drosophila melanogaster)
Active MAPKAP kinase [nucleoplasm] (Drosophila melanogaster)
phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Drosophila melanogaster)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Drosophila melanogaster)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Drosophila melanogaster)
Active MAPKAP kinase [nucleoplasm] (Drosophila melanogaster)
phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Drosophila melanogaster)
Toll Like Receptor 4 (TLR4) Cascade (Drosophila melanogaster)
MyD88-independent TLR4 cascade (Drosophila melanogaster)
TRIF (TICAM1)-mediated TLR4 signaling (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
activated TAK1 mediates p38 MAPK activation (Drosophila melanogaster)
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Drosophila melanogaster)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Drosophila melanogaster)
Active MAPKAP kinase [nucleoplasm] (Drosophila melanogaster)
phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Drosophila melanogaster)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Drosophila melanogaster)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Drosophila melanogaster)
Active MAPKAP kinase [nucleoplasm] (Drosophila melanogaster)
phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
activated TAK1 mediates p38 MAPK activation (Drosophila melanogaster)
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Drosophila melanogaster)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Drosophila melanogaster)
Active MAPKAP kinase [nucleoplasm] (Drosophila melanogaster)
phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Drosophila melanogaster)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Drosophila melanogaster)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Drosophila melanogaster)
Active MAPKAP kinase [nucleoplasm] (Drosophila melanogaster)
phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Drosophila melanogaster)
Toll Like Receptor 5 (TLR5) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
activated TAK1 mediates p38 MAPK activation (Drosophila melanogaster)
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Drosophila melanogaster)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Drosophila melanogaster)
Active MAPKAP kinase [nucleoplasm] (Drosophila melanogaster)
phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Drosophila melanogaster)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Drosophila melanogaster)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Drosophila melanogaster)
Active MAPKAP kinase [nucleoplasm] (Drosophila melanogaster)
phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Drosophila melanogaster)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
activated TAK1 mediates p38 MAPK activation (Drosophila melanogaster)
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Drosophila melanogaster)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Drosophila melanogaster)
Active MAPKAP kinase [nucleoplasm] (Drosophila melanogaster)
phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Drosophila melanogaster)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Drosophila melanogaster)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Drosophila melanogaster)
Active MAPKAP kinase [nucleoplasm] (Drosophila melanogaster)
phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Drosophila melanogaster)
Toll Like Receptor 9 (TLR9) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
MAP kinase activation (Drosophila melanogaster)
activated TAK1 mediates p38 MAPK activation (Drosophila melanogaster)
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Drosophila melanogaster)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Drosophila melanogaster)
Active MAPKAP kinase [nucleoplasm] (Drosophila melanogaster)
phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Drosophila melanogaster)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Drosophila melanogaster)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Drosophila melanogaster)
Active MAPKAP kinase [nucleoplasm] (Drosophila melanogaster)
phospho-p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P49071
Reference Genes
BioGPS Gene:44573
ENSEMBL:FBgn0013987
Flybase:FBgn0013987
KEGG Gene (Drosophila melanogaster):Dmel_CG3086
Monarch:44573
NCBI Gene:44573
Reference Transcript
RefSeq:NM_080030.5
RefSeq:NM_001201618.1
RefSeq:NM_176688.3
RefSeq:NM_001258607.2
Other Identifiers
143735_at
1631118_s_at
44573
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0004683
GO:0005516
GO:0005524
GO:0005634
GO:0005737
GO:0006468
GO:0009651
GO:0009931
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0023052
GO:0035556
GO:0036211
GO:0043226
GO:0045793
GO:0046328
GO:0046777
GO:0050896
GO:0051019
GO:0106310
GO:0140096
Participates
as a member of
Active MAPKAP kinase [nucleoplasm] (Drosophila melanogaster)
Other forms of this molecule
MAPKAPK2 [cytosol]
MAPKAPK3 [cytosol]
phospho-p-T222,S272-MAPKAPK2 [nucleoplasm]
phospho-p-S,2T-MAPKAPK3 [cytosol]
phospho-p-S272,T222,T334-MAPKAPK2 [cytosol]
phospho-p-S,2T-MAPKAPK3 [nucleoplasm]
MAPKAPK2 [nucleoplasm]
MAPKAPK3 [nucleoplasm]
Inferred From
p-T222,S272,T334-MAPKAPK2 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 222 (in Homo sapiens)
Coordinate
222
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 272 (in Homo sapiens)
Coordinate
272
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 334 (in Homo sapiens)
Coordinate
334
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001188547.1
,
NP_524769.1
,
NP_001245536.1
,
NP_788861.1
Flybase
FBgn0013987
PRO
P49071
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