Reactome | RAC1:GTP and MSN activate HEP

RAC1:GTP and MSN activate HEP

Stable Identifier

R-DME-450723

Type

Reaction [omitted]

Species

Drosophila melanogaster

Compartment

cytosol

ReviewStatus

5/5

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Activated RAC1:GTP and the MAP kinase kinase kinase kinase (MKKKK) orthologue Misshapen (MSN) are involved in phosphorylating and activating the MKK orthologue Hemipterous (HEP). It is likely that a MKKK orthologue, currently unknown, is involved in directly phosphorylating HEP.

Literature References

PubMed ID	Title	Journal	Year
9694801	The Drosophila Ste20-related kinase misshapen is required for embryonic dorsal closure and acts through a JNK MAPK module on an evolutionarily conserved signaling pathway Skolnik, EY, Treisman, JE, Su, YC	Genes Dev	1998
10469646	The Drosophila STE20-like kinase misshapen is required downstream of the Frizzled receptor in planar polarity signaling Feiguin, F, Paricio, N, Eaton, S, Mlodzik, M, Boutros, M	EMBO J	1999

Participants

Input

Output

Participates

as an event of

Activation of RAC1:GTP by FZ:DSH complex (Drosophila melanogaster)

This event is regulated

Positively by

Regulator

MSN [cytosol] (Drosophila melanogaster)

Regulator

PK:VANG:STAN dimer:FZ:DSH:DGO:RAC1:GTP [plasma membrane] (Drosophila melanogaster)

Authored

Williams, MG (2009-12-11)

Reviewed

Axelrod, JD (2009-11-19)

Created

Williams, MG (2009-12-17)

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