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Top2 [nucleoplasm]
Stable Identifier
R-DME-4641298
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
polySUMO2,3-TOP2A, P15348
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
SUMOylation (Drosophila melanogaster)
SUMO E3 ligases SUMOylate target proteins (Drosophila melanogaster)
SUMOylation of DNA replication proteins (Drosophila melanogaster)
PIAS4 SUMOylates TOP2A with SUMO2,3 (Drosophila melanogaster)
Top2 [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P15348
Gene Names
Top2
Reference Genes
BioGPS Gene:35225 Top2
CTD Gene:35225 Top2
ENSEMBL:FBgn0284220
FlyBase:FBgn0284220
KEGG:dme:Dmel_CG10223 Top2
Monarch:35225 Top2
NCBI Gene:35225 Top2
UCSC:P15348 Top2
Reference Transcript
RefSeq:NM_057412.5 Top2
RefSeq:NM_001273651.1 Top2
Other Identifiers
143380_at
1631837_at
35225
GO:0000070
GO:0000166
GO:0000182
GO:0000278
GO:0000400
GO:0000712
GO:0000793
GO:0000819
GO:0003677
GO:0003682
GO:0003696
GO:0003729
GO:0003824
GO:0003916
GO:0003918
GO:0005515
GO:0005524
GO:0005634
GO:0005694
GO:0005737
GO:0006259
GO:0006265
GO:0006325
GO:0007060
GO:0007076
GO:0016787
GO:0016853
GO:0016887
GO:0022414
GO:0030261
GO:0031507
GO:0046872
GO:0051310
GO:0051321
GO:0140097
GO:0140657
Participates
as an output of
PIAS4 SUMOylates TOP2A with SUMO2,3 (Drosophila melanogaster)
Other forms of this molecule
Top2 [nucleoplasm]
Top2 [nucleoplasm]
Inferred From
polySUMO2,3-TOP2A [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
sumoylated lysine (polySUMO2,3 [nucleoplasm]) at unknown position
Modification
polySUMO2,3 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_001260580.1
,
NP_476760.1
ENSEMBL
FBpp0304598
,
FBtr0081287
,
FBgn0284220
,
FBtr0332320
,
FBpp0080825
ZINC - Substances
TOP2_DROME
ZINC target
P15348
FlyBase
FBgn0284220
PRO
P15348
ZINC - Predictions - Purchasable
TOP2_DROME
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:M9PHX2 M9PHX2
0.462
2
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