Reactome | CycT [nucleoplasm]

CycT [nucleoplasm]

Stable Identifier

R-DME-51611

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

CCNT1, O96433

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Drosophila melanogaster)

- RNA Polymerase II Transcription (Drosophila melanogaster)
  - Generic Transcription Pathway (Drosophila melanogaster)
    - Transcriptional Regulation by TP53 (Drosophila melanogaster)
      - TP53 Regulates Transcription of DNA Repair Genes (Drosophila melanogaster)
        
        CCNK:CDK12 binds RNA Pol II at DNA repair genes (Drosophila melanogaster)
        
        CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Drosophila melanogaster)
        
        Elongation Complex at DNA Repair Genes [nucleoplasm] (Drosophila melanogaster)
        
        Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
        
        Elongation Complex at DNA Repair Genes [nucleoplasm] (Drosophila melanogaster)
        
        Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
        
        CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Drosophila melanogaster)
        
        CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm] (Drosophila melanogaster)
        
        CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK12-phosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
        
        CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Drosophila melanogaster)
        
        Elongation Complex at DNA Repair Genes [nucleoplasm] (Drosophila melanogaster)
        
        Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Drosophila melanogaster)
        
        Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Drosophila melanogaster)
        
        CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
  - RNA Polymerase II Pre-transcription Events (Drosophila melanogaster)
    - 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Drosophila melanogaster)
      - Paused processive elongation complex [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
      - Processive elongation complex [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
    - 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Drosophila melanogaster)
      - Processive elongation complex [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
    - Abortive termination of elongation after arrest (Drosophila melanogaster)
      - Aborted elongation complex after arrest [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
      - Processive elongation complex [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
    - Formation of P-TEFb complex (Drosophila melanogaster)
      - CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
      - P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
    - Resumption of elongation after recovery from pausing (Drosophila melanogaster)
      - Paused processive elongation complex [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
      - Processive elongation complex [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
    - TFIIS-mediated recovery of elongation from arrest (Drosophila melanogaster)
      - Processive elongation complex [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
  - RNA Polymerase II Transcription Elongation (Drosophila melanogaster)
    - Addition of nucleotides leads to transcript elongation (Drosophila melanogaster)
      - Elongation complex [nucleoplasm] (Drosophila melanogaster)
        
        Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
      - Processive elongation complex [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
    - Formation of RNA Pol II elongation complex (Drosophila melanogaster)
      - Recruitment of elongation factors to form elongation complex (Drosophila melanogaster)
        
        Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
        
        Elongation complex [nucleoplasm] (Drosophila melanogaster)
        
        Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
    - Pol II elongation complex moves on the template as transcript elongates (Drosophila melanogaster)
      - Elongation complex prior to separation [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
      - Processive elongation complex [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
    - Separation of elongating transcript from template (Drosophila melanogaster)
      - Elongation complex prior to separation [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
      - Elongation complex with separated and uncleaved transcript [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
  - RNA polymerase II transcribes snRNA genes (Drosophila melanogaster)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
    - CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
    - Integrator complex processes the 3' end of snRNA (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
    - RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Drosophila melanogaster)
      - Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Signaling by Nuclear Receptors (Drosophila melanogaster)
  - ESR-mediated signaling (Drosophila melanogaster)
    - Estrogen-dependent gene expression (Drosophila melanogaster)
      - ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Drosophila melanogaster)
        
        ESR1:ESTG:P-TEFb [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Drosophila melanogaster)
        
        ESR1:ESTG:P-TEFb [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
      - p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Drosophila melanogaster)
        
        MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Drosophila melanogaster)
        
        ESR1:ESTG:P-TEFb [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Drosophila melanogaster)
        
        ESR1:ESTG:P-TEFb [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)
- Signaling by TGFB family members (Drosophila melanogaster)
  - Signaling by TGF-beta Receptor Complex (Drosophila melanogaster)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Drosophila melanogaster)
        
        Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Drosophila melanogaster)
        
        CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Drosophila melanogaster)
        
        P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)
        
        CycT [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:O96433

Gene Names

CycT

Reference Genes

BioGPS Gene:39961 CycT

ENSEMBL:FBgn0025455

Flybase:FBgn0025455

KEGG Gene (Drosophila melanogaster):Dmel_CG6292 CycT

Monarch:39961 CycT

NCBI Gene:39961 CycT

Reference Transcript

Other Identifiers

153091_at

1637897_at

39961

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005700

GO:0005703

GO:0006351

GO:0006355

GO:0006357

GO:0007419

GO:0008023

GO:0008024

GO:0009408

GO:0016538

GO:0016740

GO:0032783

GO:0032786

GO:0032968

GO:0036211

GO:0043226

GO:0043229

GO:0048856

GO:0061575

GO:0070691

GO:0070816

GO:0098772

Participates

as a component of

P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Drosophila melanogaster)

as a member of

CCNT1,CCNT2,CCNK [nucleoplasm] (Drosophila melanogaster)

Other forms of this molecule

CycT [nucleoplasm]

Inferred From

CCNT1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_524127.2, NP_001261993.1, NP_996117.1, NP_001261992.1

Flybase

FBgn0025455

PRO

O96433

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O17432	1	CDK9 [nucleoplasm] (R-DME-51801)	0.656	3

Cite Us!