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Cdk9 [nucleoplasm]
Stable Identifier
R-DME-51801
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
CDK9, O17432
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional Regulation by TP53 (Drosophila melanogaster)
TP53 Regulates Transcription of DNA Repair Genes (Drosophila melanogaster)
CCNK:CDK12 binds RNA Pol II at DNA repair genes (Drosophila melanogaster)
CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Drosophila melanogaster)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Drosophila melanogaster)
Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Drosophila melanogaster)
Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Drosophila melanogaster)
CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm] (Drosophila melanogaster)
CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Drosophila melanogaster)
CDK12-phosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Drosophila melanogaster)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Drosophila melanogaster)
Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Drosophila melanogaster)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Drosophila melanogaster)
CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
RNA Polymerase II Pre-transcription Events (Drosophila melanogaster)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Drosophila melanogaster)
Paused processive elongation complex [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
Processive elongation complex [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Drosophila melanogaster)
Processive elongation complex [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
Abortive termination of elongation after arrest (Drosophila melanogaster)
Aborted elongation complex after arrest [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
Processive elongation complex [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
Formation of P-TEFb complex (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
Resumption of elongation after recovery from pausing (Drosophila melanogaster)
Paused processive elongation complex [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
Processive elongation complex [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
TFIIS-mediated recovery of elongation from arrest (Drosophila melanogaster)
Processive elongation complex [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
RNA Polymerase II Transcription Elongation (Drosophila melanogaster)
Addition of nucleotides leads to transcript elongation (Drosophila melanogaster)
Elongation complex [nucleoplasm] (Drosophila melanogaster)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
Processive elongation complex [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
Formation of RNA Pol II elongation complex (Drosophila melanogaster)
Recruitment of elongation factors to form elongation complex (Drosophila melanogaster)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
Elongation complex [nucleoplasm] (Drosophila melanogaster)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
Pol II elongation complex moves on the template as transcript elongates (Drosophila melanogaster)
Elongation complex prior to separation [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
Processive elongation complex [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
Separation of elongating transcript from template (Drosophila melanogaster)
Elongation complex prior to separation [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
RNA polymerase II transcribes snRNA genes (Drosophila melanogaster)
CBCAP complex binds 7-methylguanosine cap of snRNA (Drosophila melanogaster)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Drosophila melanogaster)
RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Drosophila melanogaster)
RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
Integrator complex processes the 3' end of snRNA (Drosophila melanogaster)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
Pre-snRNA is elongated and capped with 7-methylguanosine (Drosophila melanogaster)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
Pre-snRNA transcript initiation, Integrator binding, LEC binding (Drosophila melanogaster)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Drosophila melanogaster)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Drosophila melanogaster)
RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Signaling by Nuclear Receptors (Drosophila melanogaster)
ESR-mediated signaling (Drosophila melanogaster)
Estrogen-dependent gene expression (Drosophila melanogaster)
ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Drosophila melanogaster)
ESR1:ESTG:P-TEFb [nucleoplasm] (Drosophila melanogaster)
P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Drosophila melanogaster)
ESR1:ESTG:P-TEFb [nucleoplasm] (Drosophila melanogaster)
P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Drosophila melanogaster)
ESR1:ESTG:P-TEFb [nucleoplasm] (Drosophila melanogaster)
P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Drosophila melanogaster)
ESR1:ESTG:P-TEFb [nucleoplasm] (Drosophila melanogaster)
P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
Signaling by TGFB family members (Drosophila melanogaster)
Signaling by TGF-beta Receptor Complex (Drosophila melanogaster)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Drosophila melanogaster)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Drosophila melanogaster)
CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Drosophila melanogaster)
P-TEFb complex [nucleoplasm] (Drosophila melanogaster)
Cdk9 [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:O17432
Gene Names
Cdk9
Reference Genes
BioGPS Gene:37586 Cdk9
ENSEMBL:FBgn0019949
Flybase:FBgn0019949
KEGG Gene (Drosophila melanogaster):Dmel_CG5179 Cdk9
Monarch:37586 Cdk9
NCBI Gene:37586 Cdk9
UCSC:O17432 Cdk9
Reference Transcript
RefSeq:NM_057878.4 Cdk9
Other Identifiers
143906_at
1629487_at
37586
GO:0000166
GO:0000228
GO:0000307
GO:0000790
GO:0002230
GO:0002376
GO:0003674
GO:0003677
GO:0003723
GO:0003746
GO:0004672
GO:0004674
GO:0004693
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005700
GO:0005703
GO:0006351
GO:0006368
GO:0006412
GO:0006414
GO:0006464
GO:0006468
GO:0006950
GO:0007049
GO:0008024
GO:0008134
GO:0008135
GO:0008150
GO:0008353
GO:0009058
GO:0009408
GO:0016301
GO:0016310
GO:0016592
GO:0016740
GO:0030332
GO:0032783
GO:0032968
GO:0032991
GO:0034641
GO:0043167
GO:0043226
GO:0044212
GO:0045944
GO:0051726
GO:0070816
Participant Of
hasComponent
P-TEFb complex [nucleoplasm]
P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm]
input
Formation of P-TEFb complex
Inferred From
CDK9 [nucleoplasm] (Homo sapiens)
Cross References
RefSeq
NP_477226.2
Flybase
FBgn0019949
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O96433
2
CycT [nucleoplasm]
(R-DME-51611)
CycT [nucleoplasm]
(R-DME-51613)
0.656
3
UniProt:A8DYL7 A8DYL7
0.602
3
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