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Apc [cytosol]
Stable Identifier
R-DME-5246690
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
K63polyUb-APC, Q9VAS9
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Deubiquitination (Drosophila melanogaster)
Ovarian tumor domain proteases (Drosophila melanogaster)
ZRANB1 binds APC (Drosophila melanogaster)
Apc [cytosol] (Drosophila melanogaster)
ZRANB1:K63polyUb-APC [cytosol] (Drosophila melanogaster)
Apc [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Signaling by WNT (Drosophila melanogaster)
Degradation of beta-catenin by the destruction complex (Drosophila melanogaster)
AXIN is phosphorylated in the destruction complex (Drosophila melanogaster)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
Apc [cytosol] (Drosophila melanogaster)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
Apc [cytosol] (Drosophila melanogaster)
Association of beta-catenin with the destruction complex (Drosophila melanogaster)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
Apc [cytosol] (Drosophila melanogaster)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
Apc [cytosol] (Drosophila melanogaster)
Beta-catenin phosphorylation cascade (Drosophila melanogaster)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Drosophila melanogaster)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
Apc [cytosol] (Drosophila melanogaster)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
Apc [cytosol] (Drosophila melanogaster)
Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Drosophila melanogaster)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
Apc [cytosol] (Drosophila melanogaster)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
Apc [cytosol] (Drosophila melanogaster)
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Drosophila melanogaster)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
Apc [cytosol] (Drosophila melanogaster)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
Apc [cytosol] (Drosophila melanogaster)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Drosophila melanogaster)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
Apc [cytosol] (Drosophila melanogaster)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
Apc [cytosol] (Drosophila melanogaster)
Phosphorylation of APC component of the destruction complex (Drosophila melanogaster)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
Apc [cytosol] (Drosophila melanogaster)
ZRANB1 binds APC (Drosophila melanogaster)
Apc [cytosol] (Drosophila melanogaster)
ZRANB1:K63polyUb-APC [cytosol] (Drosophila melanogaster)
Apc [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9VAS9
Gene Names
Apc
Reference Genes
ENSEMBL:FBgn0015589
FlyBase:FBgn0015589
UCSC:Q9VAS9 Apc
Other Identifiers
143828_at
1628548_at
44642
GO:0001708
GO:0005515
GO:0005737
GO:0005829
GO:0005881
GO:0007010
GO:0007026
GO:0007163
GO:0007367
GO:0007389
GO:0007399
GO:0007405
GO:0007420
GO:0007447
GO:0008013
GO:0008017
GO:0008092
GO:0009653
GO:0016055
GO:0016342
GO:0016477
GO:0030178
GO:0030424
GO:0030707
GO:0030720
GO:0030877
GO:0030951
GO:0035293
GO:0043226
GO:0043231
GO:0045177
GO:0046673
GO:0048856
GO:0048870
GO:0071944
GO:0090090
GO:1905126
Participates
as an input of
ZRANB1 binds APC (Drosophila melanogaster)
as a component of
ZRANB1:K63polyUb-APC [cytosol] (Drosophila melanogaster)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)
Other forms of this molecule
Apc [nucleoplasm]
phospho-Apc [cytosol]
Apc [cytosol]
Apc [cytosol]
Apc [cytosol]
Inferred From
K63polyUb-APC [cytosol]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (K63polyUb [cytosol]) at unknown position
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
ENSEMBL
FBpp0084720
,
FBtr0085351
,
FBpp0307743
,
FBgn0015589
,
FBtr0336767
FlyBase
FBgn0015589
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