CLK:CYC heterodimer dissociates from per, tim, vri, and Pdp1 genes

Stable Identifier
R-DME-538891
Type
Reaction [dissociation]
Species
Drosophila melanogaster
Compartment
ReviewStatus
5/5
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The deactivation of the Clock (CLK):Cycle (CYC) heterodimer and subsequent deactivation of the per, tim, vri, and Pdp1 target genes causes the CLK:CYC heterodimer to be released from its binding to its target genes, sequestered in a stable complex with PER and TIM to reinforce the transcription inhibition. Towards the end of the night Period (PER) and Timeless (TIM) proteins are at their peak level.
Literature References
PubMed ID Title Journal Year
10409723 PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcription

Bae, K, Edery, I, Lee, C

Mol Cell Biol 1999
16543224 PER-dependent rhythms in CLK phosphorylation and E-box binding regulate circadian transcription

Dauwalder, B, Hardin, PE, Zheng, H, Houl, JH, Yu, W

Genes Dev 2006
20159956 Dynamic PER repression mechanisms in the Drosophila circadian clock: from on-DNA to off-DNA

Menet, JS, Rosbash, M, Abruzzi, KC, Desrochers, J, Rodriguez, J

Genes Dev 2010
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