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PAR-PARP1,PAR-PARP2 dimers [nucleoplasm]
Stable Identifier
R-DME-5651709
Type
Complex
Species
Drosophila melanogaster
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
DNA Repair (Drosophila melanogaster)
Base Excision Repair (Drosophila melanogaster)
Resolution of Abasic Sites (AP sites) (Drosophila melanogaster)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Drosophila melanogaster)
POLB-Dependent Long Patch Base Excision Repair (Drosophila melanogaster)
PARG dePARylates PARP1,PARP2 (Drosophila melanogaster)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
DNA Double-Strand Break Repair (Drosophila melanogaster)
Homology Directed Repair (Drosophila melanogaster)
HDR through MMEJ (alt-NHEJ) (Drosophila melanogaster)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Drosophila melanogaster)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
Nucleotide Excision Repair (Drosophila melanogaster)
Global Genome Nucleotide Excision Repair (GG-NER) (Drosophila melanogaster)
DNA Damage Recognition in GG-NER (Drosophila melanogaster)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Drosophila melanogaster)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Drosophila melanogaster)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
Dual Incision in GG-NER (Drosophila melanogaster)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Drosophila melanogaster)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Drosophila melanogaster)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Drosophila melanogaster)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Drosophila melanogaster)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Drosophila melanogaster)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
DNA polymerases delta, epsilon or kappa bind the GG-NER site (Drosophila melanogaster)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Drosophila melanogaster)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
Formation of Incision Complex in GG-NER (Drosophila melanogaster)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Drosophila melanogaster)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Drosophila melanogaster)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Drosophila melanogaster)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Drosophila melanogaster)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Drosophila melanogaster)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Drosophila melanogaster)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Drosophila melanogaster)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Drosophila melanogaster)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Drosophila melanogaster)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Drosophila melanogaster)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Drosophila melanogaster)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
Recruitment of XPA and release of CAK (Drosophila melanogaster)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Drosophila melanogaster)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Drosophila melanogaster)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Drosophila melanogaster)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Drosophila melanogaster)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
SUMOylation of XPC (Drosophila melanogaster)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Drosophila melanogaster)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Drosophila melanogaster)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
TFIIH binds GG-NER site to form a verification complex (Drosophila melanogaster)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Drosophila melanogaster)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Drosophila melanogaster)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Drosophila melanogaster)
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] (Drosophila melanogaster)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
PAR-PARP1 [nucleoplasm]
(Drosophila melanogaster)
Participates
as an input of
PARG dePARylates PARP1,PARP2 (Drosophila melanogaster)
as a component of
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Drosophila melanogaster)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Drosophila melanogaster)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Drosophila melanogaster)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Drosophila melanogaster)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Drosophila melanogaster)
as an output of
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Drosophila melanogaster)
Inferred From
PAR-PARP1,PAR-PARP2 dimers [nucleoplasm]
(Homo sapiens)
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