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'activator' RAFs [cytosol]
Stable Identifier
R-DME-5672709
Type
Set [CandidateSet]
Species
Drosophila melanogaster
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
MAP2K and MAPK activation (Drosophila melanogaster)
Dissociation of RAS:RAF complex (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
Dual mechanism MAPK inhibitors bind MAPKs (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
MAP2Ks and MAPKs bind to the activated RAF complex (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Drosophila melanogaster)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
MAP2Ks phosphorylate MAPKs (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
RAF phosphorylates MAP2K dimer (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAF:YWHAB dimer [cytosol] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
Negative regulation of MAPK pathway (Drosophila melanogaster)
PEBP1 binds activated RAF1 (Drosophila melanogaster)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Drosophila melanogaster)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
PP2A dephosphorylates RAF1 (Drosophila melanogaster)
p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
p21RAS:GTP:p-S621 RAF1 homo/heterodimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
PP5 dephosphorylates RAF1 S338 (Drosophila melanogaster)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
RAF activation (Drosophila melanogaster)
"Activator" RAF:YWHAB dimer binds RAS:GTP (Drosophila melanogaster)
'activator' RAF:YWHAB dimer [cytosol] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAF:YWHAB dimer [cytosol] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
Phosphorylation of RAF (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAF:YWHAB dimer [cytosol] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAF:YWHAB dimer [cytosol] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAF:YWHAB dimer [cytosol] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
Raf dimer inhibitors bind RAF heterodimers (Drosophila melanogaster)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAF:YWHAB dimer [cytosol] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAF:YWHAB dimer [cytosol] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
Participants
members
phospho-p-S446,S729-BRAF [cytosol]
(Drosophila melanogaster)
candidates
phospho-p-S299,S302,T452,T455,S582 ARAF [cytosol]
(Drosophila melanogaster)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
(Drosophila melanogaster)
phospho-p-S446,T599,S602,S729 BRAF [cytosol]
(Drosophila melanogaster)
phospho-p-S311,Y602 KSR1 [cytosol]
(Drosophila melanogaster)
Participates
as a component of
p21RAS:GTP:p-S621 RAF1 homo/heterodimer [plasma membrane] (Drosophila melanogaster)
p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Drosophila melanogaster)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Drosophila melanogaster)
'activator' RAF:YWHAB dimer [cytosol] (Drosophila melanogaster)
p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
Inferred From
'activator' RAFs [cytosol]
(Homo sapiens)
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