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phospho-hyperphosphorylated RAF1 [plasma membrane]
Stable Identifier
R-DME-5675193
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
plasma membrane
Synonyms
P11346
Locations in the PathwayBrowser
Expand all
Signal Transduction (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
Negative regulation of MAPK pathway (Drosophila melanogaster)
Negative feedback regulation of MAPK pathway (Drosophila melanogaster)
Activated MAPK phosphorylates RAF1 (Drosophila melanogaster)
phospho-hyperphosphorylated RAF1 [plasma membrane] (Drosophila melanogaster)
PP2A dephosphorylates RAF1 (Drosophila melanogaster)
phospho-hyperphosphorylated RAF1 [plasma membrane] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P11346 Raf
Gene Names
Raf, ph, phl, CG2845
Chain
chain:1-739
Reference Genes
BioGPS Gene:31221 Raf
KEGG:dme:Dmel_CG2845 Raf
Monarch:31221 Raf
NCBI Gene:31221 Raf
UCSC:P11346 Raf
Reference Transcript
RefSeq:NM_080308.4 Raf
RefSeq:NM_001103397.3 Raf
Other Identifiers
143302_at
1627470_at
31221
GO:0000165
GO:0002168
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004709
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0005886
GO:0006468
GO:0007163
GO:0007165
GO:0007173
GO:0007265
GO:0007283
GO:0007298
GO:0007362
GO:0007369
GO:0007427
GO:0007430
GO:0007465
GO:0007472
GO:0007474
GO:0007476
GO:0007552
GO:0008069
GO:0008284
GO:0008293
GO:0008543
GO:0009267
GO:0016242
GO:0016740
GO:0019900
GO:0022414
GO:0030154
GO:0030641
GO:0035171
GO:0035309
GO:0040014
GO:0042051
GO:0042386
GO:0042461
GO:0045500
GO:0046530
GO:0046534
GO:0046777
GO:0046843
GO:0046872
GO:0048010
GO:0048856
GO:0048870
GO:0070371
GO:0070374
GO:0106310
GO:0140096
GO:2001234
Participates
as an output of
Activated MAPK phosphorylates RAF1 (Drosophila melanogaster)
This entity regulates
Positively
PP2A dephosphorylates RAF1
(Drosophila melanogaster)
Other forms of this molecule
Phospho PHL [plasma membrane]
PHL [cytosol]
phospho-p-S299,S302,T452,T455,S582 ARAF [cytosol]
phospho-p-S446,T599,S602,S729 BRAF [cytosol]
phospho-p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
phospho-p-S446,S729-BRAF [cytosol]
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane]
phospho-p-S299,S302,T452,T455,S582 ARAF [plasma membrane]
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
phospho-p-S582 ARAF [cytosol]
phospho-p-S621-RAF1 [cytosol]
RAF1 [cytosol]
BRAF [cytosol]
phospho-p-S214,S582 ARAF [cytosol]
phospho-p-S259,S621-RAF1 [cytosol]
phospho-p-S365,S446,S729 BRAF [cytosol]
phospho-p-Y341,T491,S494,S621 RAF1 [plasma membrane]
phospho-p-S621-RAF1 [plasma membrane]
phospho-hyperphosphorylated BRAF [plasma membrane]
phospho-p-S338-RAF1 [cytosol]
phospho-p-S338,Y340,Y341-RAF1 [cytosol]
Inferred From
hyperphosphorylated RAF1 [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 621 (in Homo sapiens)
Coordinate
621
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O4'-phospho-L-tyrosine at 341 (in Homo sapiens)
Coordinate
341
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O-phospho-L-serine at 338 (in Homo sapiens)
Coordinate
338
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 491 (in Homo sapiens)
Coordinate
491
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 494 (in Homo sapiens)
Coordinate
494
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 29 (in Homo sapiens)
Coordinate
29
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 43 (in Homo sapiens)
Coordinate
43
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 259 (in Homo sapiens)
Coordinate
259
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 296 (in Homo sapiens)
Coordinate
296
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 301 (in Homo sapiens)
Coordinate
301
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 642 (in Homo sapiens)
Coordinate
642
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001096867.3
,
NP_525047.1
ENSEMBL
FBpp0070385
,
FBtr0344007
,
FBtr0070401
,
FBpp0310458
IntEnz
2.7.11.1
FlyBase
FBgn0003079
PRO
P11346
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q24324 Dsor1
9
DSOR1 [cytosol]
(R-DME-205968)
phospho-p-S,218, S222,T292 MAP2K1 [cytosol]
(R-DME-5674490)
phospho-p-S,T-MAP2K2 [cytosol]
(R-DME-109848)
phospho-p-T286,T292-MAP2K1 [cytosol]
(R-DME-112374)
phospho-p-S218,S222,T286,T292-MAP2K1 [cytosol]
(R-DME-112339)
MAP2K1 [cytosol]
(R-DME-59502)
MAP2K2 [cytosol]
(R-DME-59504)
phospho-p-S222,S226-MAP2K2 [cytosol]
(R-DME-169292)
phospho-p-S218,S222-MAP2K1 [cytosol]
(R-DME-109837)
0.667
5
UniProt:P00528
20
SRC-2 [cytosol]
(R-DME-191648)
phospho-MyrG-p-Y419-SRC [plasma membrane]
(R-DME-1810408)
FYN [cytosol]
(R-DME-200917)
LCK [cytosol]
(R-DME-167609)
SRC-1 [plasma membrane]
(R-DME-65043)
phospho-MyrG-p-Y426-YES1 [plasma membrane]
(R-DME-1810411)
phospho-MyrG-p-Y420-FYN-1 [plasma membrane]
(R-DME-9032530)
phospho-MyrG,p-Y530-SRC [plasma membrane]
(R-DME-377598)
phospho-p-Y420-FYN [cytosol]
(R-DME-391821)
LYN [cytosol]
(R-DME-354251)
phospho-p-Y419-SRC [cytosol]
(R-DME-377592)
FGR [cytosol]
(R-DME-432116)
YES1 [cytosol]
(R-DME-373640)
HCK [cytosol]
(R-DME-167708)
MyrG2-PalmC3-LYN [plasma membrane]
(R-DME-9606875)
phospho-p-Y397-LYN [plasma membrane]
(R-DME-2454229)
phospho-p-Y397-LYN [cytosol]
(R-DME-8942608)
LYN [plasma membrane]
(R-DME-197943)
phospho-p-Y394-LCK [plasma membrane]
(R-DME-8857940)
phospho-p-Y419-SRC-1 [plasma membrane]
(R-DME-112331)
0.544
3
UniProt:P08646 Ras85D
20
phospho-p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane]
(R-DME-9674821)
NRAS [tertiary granule membrane]
(R-DME-6800190)
RAS85D [plasma membrane]
(R-DME-205933)
phospho-pS181-S-Farn-Me KRAS4B [mitochondrial outer membrane]
(R-DME-9653578)
S-Farn-Me HRAS [plasma membrane]
(R-DME-9665052)
S-Farn-Me PalmS KRAS4A [Golgi membrane]
(R-DME-9647903)
S-Farn-Me PalmS HRAS [Golgi membrane]
(R-DME-9647896)
S-Farn-Me PalmS NRAS [Golgi membrane]
(R-DME-9647906)
S-Farn-Me KRAS4B [cytosol]
(R-DME-9654510)
phospho-pS181-S-Farn-Me KRAS4B [plasma membrane]
(R-DME-9653482)
S-Farn-Me KRAS4B [endoplasmic reticulum membrane]
(R-DME-9649690)
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(R-DME-9647796)
S-Farn-KRAS [endoplasmic reticulum membrane]
(R-DME-9647790)
S-Farn NRAS [endoplasmic reticulum membrane]
(R-DME-9647782)
S-Farn KRAS4B [endoplasmic reticulum membrane]
(R-DME-9649698)
S-Farn proKRAS4B [endoplasmic reticulum membrane]
(R-DME-9649693)
S-Farn-proNRAS [endoplasmic reticulum membrane]
(R-DME-9647928)
S-Farn-proKRAS [endoplasmic reticulum membrane]
(R-DME-9647925)
proKRAS [cytosol]
(R-DME-9647762)
pro-KRAS4A [cytosol]
(R-DME-9649683)
0.502
2
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