Reactome | IntS2 [nucleoplasm]

IntS2 [nucleoplasm]

Stable Identifier

R-DME-6807448

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

INTS2, Q9VX31

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Drosophila melanogaster)

- RNA Polymerase II Transcription (Drosophila melanogaster)
  - RNA polymerase II transcribes snRNA genes (Drosophila melanogaster)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Drosophila melanogaster)
        
        Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS2 [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Drosophila melanogaster)
        
        Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS2 [nucleoplasm] (Drosophila melanogaster)
    - Integrator complex processes the 3' end of snRNA (Drosophila melanogaster)
      - Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS2 [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Drosophila melanogaster)
        
        Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS2 [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Drosophila melanogaster)
        
        Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS2 [nucleoplasm] (Drosophila melanogaster)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Drosophila melanogaster)
        
        Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS2 [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Drosophila melanogaster)
        
        Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS2 [nucleoplasm] (Drosophila melanogaster)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Drosophila melanogaster)
      - Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS2 [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Drosophila melanogaster)
        
        Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS2 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9VX31

Gene Names

IntS2

Reference Genes

BioGPS Gene:32745 IntS2

ENSEMBL:FBgn0030858

FlyBase:FBgn0030858

KEGG:dme:Dmel_CG8211 IntS2

Monarch:32745 IntS2

NCBI Gene:32745 IntS2

UCSC:Q9VX31 IntS2

Reference Transcript

RefSeq:NM_133004.2 IntS2

Other Identifiers

153910_at

1629279_at

32745

GO:0003674

GO:0005634

GO:0005737

GO:0010628

GO:0016020

GO:0016073

GO:0016180

GO:0031965

GO:0032039

GO:0034472

GO:0043226

GO:0045666

Participates

as a component of

Integrator [nucleoplasm] (Drosophila melanogaster)

Inferred From

INTS2 [nucleoplasm] (Homo sapiens)

Cross References

ENSEMBL

FBgn0030858, FBtr0074480, FBpp0074254

FlyBase

FBgn0030858

PRO

Q9VX31