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CDK2 [nucleoplasm]
Stable Identifier
R-DME-68365
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
P23573
Locations in the PathwayBrowser
Expand all
Cell Cycle (Drosophila melanogaster)
Cell Cycle Checkpoints (Drosophila melanogaster)
G1/S DNA Damage Checkpoints (Drosophila melanogaster)
p53-Dependent G1/S DNA damage checkpoint (Drosophila melanogaster)
p53-Dependent G1 DNA Damage Response (Drosophila melanogaster)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Drosophila melanogaster)
CCNA:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Drosophila melanogaster)
CCNA:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Drosophila melanogaster)
CCNE:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] (Drosophila melanogaster)
CCNE:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
G2/M Checkpoints (Drosophila melanogaster)
Activation of ATR in response to replication stress (Drosophila melanogaster)
Activation of claspin (Drosophila melanogaster)
Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDK [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDK [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Loading of claspin onto DNA during replication origin firing (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDK [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDK [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
Mitotic G1 phase and G1/S transition (Drosophila melanogaster)
G0 and Early G1 (Drosophila melanogaster)
p107 (RBL1) binds CyclinE/A:CDK2 (Drosophila melanogaster)
Cyclin E/A:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
RBL1:Cyclin E/A:CDK2 [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Drosophila melanogaster)
Cyclin E/A:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
RBL1:E2F4:DP1/2:Cyclin E/A:CDK2 [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
p130 (RBL2) binds Cyclin E/A:CDK2 (Drosophila melanogaster)
Cyclin E/A:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
RBL2:Cyclin E/A:CDK2 [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Drosophila melanogaster)
Cyclin E/A:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
RBL2:E2F4/5:DP1/2:Cyclin E/A:CDK2 [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
G1/S Transition (Drosophila melanogaster)
Activation of the pre-replicative complex (Drosophila melanogaster)
Cdc45 associates with the pre-replicative complex at the origin (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDK [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDK [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDK [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDK [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
DNA polymerase alpha:primase binds at the origin (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDK [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon binds at the origin (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDK [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Cyclin E associated events during G1/S transition (Drosophila melanogaster)
CAK-mediated phosphorylation of Cyclin E:Cdk2 (Drosophila melanogaster)
CCNE:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Drosophila melanogaster)
CCNE:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Drosophila melanogaster)
CCNE:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] (Drosophila melanogaster)
CCNE:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Drosophila melanogaster)
CCNE:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Translocation of Cyclin E:Cdk2 complex to the nucleus (Drosophila melanogaster)
CCNE:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
S Phase (Drosophila melanogaster)
Cyclin A:Cdk2-associated events at S phase entry (Drosophila melanogaster)
CAK-mediated phosphorylation of Cyclin A:Cdk2 (Drosophila melanogaster)
CCNA:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Drosophila melanogaster)
CCNA:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Drosophila melanogaster)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Drosophila melanogaster)
CCNA:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Cyclin A:Cdk2:phospho-p27/p21 complex [nucleoplasm] (Drosophila melanogaster)
CCNA:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Drosophila melanogaster)
CCNA:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Drosophila melanogaster)
CCNA:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Drosophila melanogaster)
CCNA:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Translocation of Cyclin A:Cdk2 complexes to the nucleus (Drosophila melanogaster)
CCNA:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular Senescence (Drosophila melanogaster)
DNA Damage/Telomere Stress Induced Senescence (Drosophila melanogaster)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Drosophila melanogaster)
CCNA:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Drosophila melanogaster)
CCNA:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Drosophila melanogaster)
CCNE:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] (Drosophila melanogaster)
CCNE:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Senescence-Associated Secretory Phenotype (SASP) (Drosophila melanogaster)
CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Drosophila melanogaster)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Drosophila melanogaster)
CCNA:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Drosophila melanogaster)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Drosophila melanogaster)
CCNA:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
DNA Replication (Drosophila melanogaster)
DNA Replication Pre-Initiation (Drosophila melanogaster)
Activation of the pre-replicative complex (Drosophila melanogaster)
Cdc45 associates with the pre-replicative complex at the origin (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDK [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDK [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDK [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDK [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
DNA polymerase alpha:primase binds at the origin (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDK [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
DNA polymerase epsilon binds at the origin (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
CDK [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Developmental Biology (Drosophila melanogaster)
Transcriptional regulation of granulopoiesis (Drosophila melanogaster)
CEBPA binds CDK2 (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
CEBPA:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional Regulation by TP53 (Drosophila melanogaster)
TP53 Regulates Transcription of Cell Cycle Genes (Drosophila melanogaster)
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Drosophila melanogaster)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Drosophila melanogaster)
CCNA:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Drosophila melanogaster)
CCNA:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Drosophila melanogaster)
CCNE:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] (Drosophila melanogaster)
CCNE:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK2 [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P23573
Reference Genes
BioGPS Gene:42453
ENSEMBL:FBgn0004107
FlyBase:FBgn0004107
KEGG:dme:Dmel_CG10498
Monarch:42453
NCBI Gene:42453
UCSC:P23573
Reference Transcript
RefSeq:NM_079696.6
RefSeq:NM_001170195.3
RefSeq:NM_169916.3
Other Identifiers
154093_at
1640394_s_at
42453
GO:0000082
GO:0000086
GO:0000307
GO:0003824
GO:0004672
GO:0004674
GO:0004693
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0006355
GO:0006357
GO:0006468
GO:0007165
GO:0008284
GO:0008353
GO:0010389
GO:0010468
GO:0016740
GO:0030332
GO:0043226
GO:0046427
GO:0051301
GO:0051726
GO:0106310
GO:0140096
Participates
as an input of
CEBPA binds CDK2 (Drosophila melanogaster)
as a component of
CEBPA:CDK2 [nucleoplasm] (Drosophila melanogaster)
Cyclin E/A:CDK2 [nucleoplasm] (Drosophila melanogaster)
CCNE:CDK2 [nucleoplasm] (Drosophila melanogaster)
CCNA:CDK2 [nucleoplasm] (Drosophila melanogaster)
CDK [nucleoplasm] (Drosophila melanogaster)
Other forms of this molecule
phospho-p-Y15-CDK2 [nucleoplasm]
phospho-p-CDK2 [nucleoplasm]
CDK2 [cytosol]
phospho-p-T160-CDK2 [nucleoplasm]
Inferred From
CDK2 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001163666.1
,
NP_524420.1
,
NP_732544.1
ENSEMBL
FBgn0004107
,
FBtr0300447
,
FBtr0083922
,
FBpp0289675
,
FBpp0083330
,
FBpp0083329
,
FBtr0083921
IntEnz
2.7.11.22
FlyBase
FBgn0004107
PRO
P23573
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q24159 Q24159
0.818
6
UniProt:Q961D1
1
CycK [nucleoplasm]
(R-DME-6796619)
0.712
5
UniProt:P91654 P91654
0.621
3
UniProt:Q9VJ42 Q9VJ42
0.553
2
UniProt:P54733
4
CycE [cytosol]
(R-DME-157452)
CycE [nucleoplasm]
(R-DME-68367)
CycE [nucleoplasm]
(R-DME-68363)
CycE [cytosol]
(R-DME-157443)
0.508
2
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