Reactome | RpS18 [cytosol]

RpS18 [cytosol]

Stable Identifier

R-DME-72341

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

RPS18, P41094

Locations in the PathwayBrowser

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Metabolism of RNA (Drosophila melanogaster)

- Nonsense-Mediated Decay (NMD) (Drosophila melanogaster)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Drosophila melanogaster)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Drosophila melanogaster)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        40S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpS18 [cytosol] (Drosophila melanogaster)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        40S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpS18 [cytosol] (Drosophila melanogaster)
    - SMG6 hydrolyzes mRNA with premature termination codon (Drosophila melanogaster)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        40S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpS18 [cytosol] (Drosophila melanogaster)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Drosophila melanogaster)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        40S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpS18 [cytosol] (Drosophila melanogaster)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        40S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpS18 [cytosol] (Drosophila melanogaster)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Drosophila melanogaster)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Drosophila melanogaster)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        40S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpS18 [cytosol] (Drosophila melanogaster)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        40S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpS18 [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:P41094

Gene Names

RpS18

Reference Genes

BioGPS Gene:37292 RpS18

ENSEMBL:FBgn0010411

Flybase:FBgn0010411

KEGG Gene (Drosophila melanogaster):Dmel_CG8900 RpS18

Monarch:37292 RpS18

NCBI Gene:37292 RpS18

Reference Transcript

Other Identifiers

143618_at

1624983_s_at

37292

GO:0000228

GO:0002181

GO:0003676

GO:0003723

GO:0003735

GO:0005198

GO:0005634

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0015935

GO:0019843

GO:0022626

GO:0022627

GO:0043226

GO:1990904

Participates

as a component of

40S ribosomal complex [cytosol] (Drosophila melanogaster)

Other forms of this molecule

RpS18 [nucleoplasm]

Inferred From

RPS18 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_476964.1, NP_725943.1

Flybase

FBgn0010411

PRO

P41094

PDB

4V6W, 6XU7, 6XU8, 6XU6

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