Reactome | RpS28b [cytosol]

RpS28b [cytosol]

Stable Identifier

R-DME-72365

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

RPS28, Q9W334

Locations in the PathwayBrowser

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Metabolism of RNA (Drosophila melanogaster)

- Nonsense-Mediated Decay (NMD) (Drosophila melanogaster)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Drosophila melanogaster)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Drosophila melanogaster)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        40S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpS28b [cytosol] (Drosophila melanogaster)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        40S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpS28b [cytosol] (Drosophila melanogaster)
    - SMG6 hydrolyzes mRNA with premature termination codon (Drosophila melanogaster)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        40S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpS28b [cytosol] (Drosophila melanogaster)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Drosophila melanogaster)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Drosophila melanogaster)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        40S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpS28b [cytosol] (Drosophila melanogaster)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        40S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpS28b [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9W334

Gene Names

RpS28b

Reference Genes

BioGPS Gene:31897 RpS28b

CTD Gene:31897 RpS28b

ENSEMBL:FBgn0030136

Flybase:FBgn0030136

KEGG Gene (Drosophila melanogaster):Dmel_CG2998 RpS28b

Monarch:31897 RpS28b

NCBI Gene:31897 RpS28b

Reference Transcript

Other Identifiers

154190_at

1624792_at

31897

GO:0000028

GO:0002181

GO:0003674

GO:0003735

GO:0005198

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0008150

GO:0009058

GO:0022607

GO:0022618

GO:0022627

GO:0030490

GO:0032991

GO:0034641

GO:0042254

GO:0043226

GO:0065003

Participant Of

hasComponent

40S ribosomal complex [cytosol]

Other forms of this molecule

RpS28b [nucleoplasm]

Inferred From

RPS28 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001285059.1, NP_572568.1

Flybase

FBgn0030136

PRO

Q9W334

PDB

4V6W

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