Reactome | RpL21 [cytosol]

RpL21 [cytosol]

Stable Identifier

R-DME-72426

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

RPL21, Q9V9M7

Locations in the PathwayBrowser

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Metabolism of RNA (Drosophila melanogaster)

- Nonsense-Mediated Decay (NMD) (Drosophila melanogaster)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Drosophila melanogaster)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Drosophila melanogaster)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        60S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpL21 [cytosol] (Drosophila melanogaster)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        60S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpL21 [cytosol] (Drosophila melanogaster)
    - SMG6 hydrolyzes mRNA with premature termination codon (Drosophila melanogaster)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        60S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpL21 [cytosol] (Drosophila melanogaster)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Drosophila melanogaster)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        60S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpL21 [cytosol] (Drosophila melanogaster)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        60S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpL21 [cytosol] (Drosophila melanogaster)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Drosophila melanogaster)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Drosophila melanogaster)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        60S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpL21 [cytosol] (Drosophila melanogaster)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        60S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpL21 [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9V9M7

Gene Names

RpL21

Reference Genes

BioGPS Gene:35453 RpL21

ENSEMBL:FBgn0032987

Flybase:FBgn0032987

KEGG Gene (Drosophila melanogaster):Dmel_CG12775 RpL21

Monarch:35453 RpL21

NCBI Gene:35453 RpL21

UCSC:Q9V9M7 RpL21

Reference Transcript

Other Identifiers

146621_at

1636712_at

35453

GO:0002181

GO:0003735

GO:0005198

GO:0005829

GO:0005840

GO:0006412

GO:0022625

GO:0022626

GO:0043226

Participates

as a component of

Inferred From

RPL21 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001260689.1, NP_610144.1, NP_001286133.1

Flybase

FBgn0032987

PDB

6XU6, 6XU8, 4V6W, 6XU7

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