Reactome | RpL40 [cytosol]

RpL40 [cytosol]

Stable Identifier

R-DME-72476

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

RPL40, P18101

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Drosophila melanogaster)

- Nonsense-Mediated Decay (NMD) (Drosophila melanogaster)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Drosophila melanogaster)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Drosophila melanogaster)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        60S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpL40 [cytosol] (Drosophila melanogaster)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        60S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpL40 [cytosol] (Drosophila melanogaster)
    - SMG6 hydrolyzes mRNA with premature termination codon (Drosophila melanogaster)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        60S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpL40 [cytosol] (Drosophila melanogaster)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Drosophila melanogaster)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Drosophila melanogaster)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        60S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpL40 [cytosol] (Drosophila melanogaster)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        60S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpL40 [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:P18101 RpL40

Gene Names

RpL40, Ubi-f, UBI-F52, CG2960

Chain

chain:1-76, chain:77-128

Reference Genes

BioGPS Gene:33629 RpL40

CTD Gene:33629 RpL40

KEGG Gene (Drosophila melanogaster):Dmel_CG2960 RpL40

Monarch:33629 RpL40

NCBI Gene:33629 RpL40

Reference Transcript

Other Identifiers

143397_at

1633277_at

33629

GO:0002181

GO:0003674

GO:0003735

GO:0005198

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0006464

GO:0006511

GO:0008150

GO:0009056

GO:0009058

GO:0015935

GO:0016567

GO:0019899

GO:0019941

GO:0022625

GO:0022627

GO:0031386

GO:0031625

GO:0032991

GO:0034641

GO:0043226

Participant Of

hasComponent

output

UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin

Other forms of this molecule

RpL40 [endocytic vesicle membrane]

RpL40 [mitochondrial outer membrane]

RpL40 [cytosol]

phospho-RpL40 [nucleoplasm]

RpL40 [cytosol]

phospho-RpL40 [cytosol]

RpL40 [cytosol]

UBI-P63E 12 [cytosol]

RpL40 [cytosol]

RpL40 [nucleoplasm]

RpL40 [cytosol]

RpL40 [endosome membrane]

RpL40 [nucleoplasm]

Inferred From

RPL40 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_476776.1, NP_001260018.1

Target Pathogen

5b354852be737e166372eb07, 5b2801b3be737e35a6deded6, 57c5e0e8be737e5a0cb48b62, 5b2801b2be737e35a6de9681, 5b2801b2be737e35a6de9e91, 57c0ab1cbe737e1cc0a9d077

Flybase

FBgn0003941

PRO

P18101

PDB

4V6W

Cite Us!