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About
What is Reactome ?
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drk [cytosol]
Stable Identifier
R-DME-74686
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
GRB2-1, Q08012
Locations in the PathwayBrowser
Expand all
Developmental Biology (Drosophila melanogaster)
Nervous system development (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
NCAM signaling for neurite out-growth (Drosophila melanogaster)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Drosophila melanogaster)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Drosophila melanogaster)
pFAK:Grb2:Sos [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
RET signaling (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-RET complexes bind GRB2 (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
FLT3 Signaling (Drosophila melanogaster)
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Drosophila melanogaster)
Active FLT3:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
Active FLT3: GRB2 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Signaling by CSF3 (G-CSF) (Drosophila melanogaster)
p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Drosophila melanogaster)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Signaling by Interleukins (Drosophila melanogaster)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Drosophila melanogaster)
Regulation of signaling by CBL (Drosophila melanogaster)
CBL ubiquitinates PI3K (Drosophila melanogaster)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Drosophila melanogaster)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
DAP12 interactions (Drosophila melanogaster)
DAP12 signaling (Drosophila melanogaster)
Activation of RAC1 by VAV2/3 (Drosophila melanogaster)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Recruitment of GADS:SLP-76 to p-5Y-LAT (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Recruitment of VAV and BTK to p-SLP-76 (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Release of p-PLCG1 (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
SOS mediated nucleotide exchange of RAS (SHC) (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
FCERI mediated Ca+2 mobilization (Drosophila melanogaster)
Autophosphorylation of BTK/ITK (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Hydrolysis of PIP2 by PLCG (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
FCERI mediated MAPK activation (Drosophila melanogaster)
Activation of RAC1 by VAV (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Autophosphorylation of PAK (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Interaction of GRB2:SOS complex with p-SHC1 (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Phosphorylation and activation of VAV (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Recruitment of GADS:SLP-76 to p-5Y-LAT (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Recruitment of PAK to the membrane by binding active RAC1 (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Recruitment of VAV to p-SLP-76 (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
SOS mediated nucleotide exchange of RAS (SHC) (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Role of LAT2/NTAL/LAB on calcium mobilization (Drosophila melanogaster)
PI3K associates with phosphorylated GAB2 (Drosophila melanogaster)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Drosophila melanogaster)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Drosophila melanogaster)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Drosophila melanogaster)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Phosphorylation of PIP2 to PIP3 by PI3K (Drosophila melanogaster)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Drosophila melanogaster)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Drosophila melanogaster)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Fcgamma receptor (FCGR) dependent phagocytosis (Drosophila melanogaster)
Regulation of actin dynamics for phagocytic cup formation (Drosophila melanogaster)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Drosophila melanogaster)
Mother filament:branching complex [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Drosophila melanogaster)
SH3 domain proteins [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Drosophila melanogaster)
SH3 domain proteins [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Detachment of WASP/WAVE (Drosophila melanogaster)
Mother filament:branching complex [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Drosophila melanogaster)
SH3 domain proteins [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Drosophila melanogaster)
SH3 domain proteins [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
Negative regulation of the PI3K/AKT network (Drosophila melanogaster)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activator:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activator:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
RAS GEFs promote RAS nucleotide exchange (Drosophila melanogaster)
RAS GEFs [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Active FLT3:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
Active FLT3: GRB2 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1:p-Y-SHC [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1:p-Y427-SHC1 [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:SOS1:p-KIT complex [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Drosophila melanogaster)
pFAK:Grb2:Sos [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
p-SHC1:GRB2:SOS [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Signaling by Erythropoietin (Drosophila melanogaster)
Erythropoietin activates RAS (Drosophila melanogaster)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Drosophila melanogaster)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:VAV1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2-1:VAV1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Signaling by GPCR (Drosophila melanogaster)
GPCR downstream signalling (Drosophila melanogaster)
G alpha (q) signalling events (Drosophila melanogaster)
Gastrin-CREB signalling pathway via PKC and MAPK (Drosophila melanogaster)
EGFR Transactivation by Gastrin (Drosophila melanogaster)
SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Drosophila melanogaster)
GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by EGFR (Drosophila melanogaster)
EGFR downregulation (Drosophila melanogaster)
Assembly of EGFR complex in clathrin-coated vesicles (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
CBL binds to GRB2 (Drosophila melanogaster)
CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Drosophila melanogaster)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGFR binds EPS15, EPN1, EPS15L1 (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGFR phosphorylates EPS15 (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Localization of CBL:GRB2 to the membrane (Drosophila melanogaster)
CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
PTPN3 dephosphorylates EPS15 (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Ubiquitination of stimulated EGFR (CBL:GRB2) (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GAB1 signalosome (Drosophila melanogaster)
Binding of GRB2 to GAB1 (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Dephosphorylation of Gab1 by SHP2 (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Drosophila melanogaster)
GRB2:p-Y627,Y659-GAB1,GRB2:p-Y627,Y659-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:Phospho-GAB1(partially dephosphorylated) [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:p-GAB1(partially dephosphorylated):PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:Phospho-GAB1(partially dephosphorylated) [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GAB1 phosphorylation by EGFR kinase (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:GAB1 binds to phosphorylated EGFR (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:GAB1,GRB2:GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
SHP2 dephosphorylates Tyr 992 on EGFR (Drosophila melanogaster)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Drosophila melanogaster)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Sustained activation of SRC kinase by SHP2 (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2 events in EGFR signaling (Drosophila melanogaster)
GRB2-1 binds SOS1 (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:SOS1 complex binds to EGF:EGFR complex (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
SHC1 events in EGFR signaling (Drosophila melanogaster)
GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Signaling by ERBB2 (Drosophila melanogaster)
GRB2 events in ERBB2 signaling (Drosophila melanogaster)
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Drosophila melanogaster)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
PI3K events in ERBB2 signaling (Drosophila melanogaster)
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Signaling by ERBB4 (Drosophila melanogaster)
SHC1 events in ERBB4 signaling (Drosophila melanogaster)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Drosophila melanogaster)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Signaling by FGFR (Drosophila melanogaster)
Signaling by FGFR1 (Drosophila melanogaster)
Downstream signaling of activated FGFR1 (Drosophila melanogaster)
FRS-mediated FGFR1 signaling (Drosophila melanogaster)
Activated FGFR1:p-FRS binds GRB2:SOS1 (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
PI-3K cascade:FGFR1 (Drosophila melanogaster)
Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
SHC-mediated cascade:FGFR1 (Drosophila melanogaster)
Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Drosophila melanogaster)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Negative regulation of FGFR1 signaling (Drosophila melanogaster)
CBL ubiquitinates FRS2 and FGFR1 (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Spry regulation of FGF signaling (Drosophila melanogaster)
SPRY2 binds GRB2 (Drosophila melanogaster)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Signaling by FGFR2 (Drosophila melanogaster)
Downstream signaling of activated FGFR2 (Drosophila melanogaster)
FRS-mediated FGFR2 signaling (Drosophila melanogaster)
Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR2:pFRS binds GRB2:SOS1 (Drosophila melanogaster)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
PI-3K cascade:FGFR2 (Drosophila melanogaster)
Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)
Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
SHC-mediated cascade:FGFR2 (Drosophila melanogaster)
Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Drosophila melanogaster)
Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)
Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Negative regulation of FGFR2 signaling (Drosophila melanogaster)
CBL ubiquitinates FRS2 and FGFR2 (Drosophila melanogaster)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Spry regulation of FGF signaling (Drosophila melanogaster)
SPRY2 binds GRB2 (Drosophila melanogaster)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Drosophila melanogaster)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Signaling by FGFR3 (Drosophila melanogaster)
Downstream signaling of activated FGFR3 (Drosophila melanogaster)
FRS-mediated FGFR3 signaling (Drosophila melanogaster)
Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR3:pFRS binds GRB2:SOS1 (Drosophila melanogaster)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
PI-3K cascade:FGFR3 (Drosophila melanogaster)
Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)
Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
SHC-mediated cascade:FGFR3 (Drosophila melanogaster)
Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Drosophila melanogaster)
Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)
Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Negative regulation of FGFR3 signaling (Drosophila melanogaster)
CBL ubiquitinates FRS2 and FGFR3 (Drosophila melanogaster)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Spry regulation of FGF signaling (Drosophila melanogaster)
SPRY2 binds GRB2 (Drosophila melanogaster)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Drosophila melanogaster)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Signaling by FGFR4 (Drosophila melanogaster)
Downstream signaling of activated FGFR4 (Drosophila melanogaster)
FRS-mediated FGFR4 signaling (Drosophila melanogaster)
Activated FGFR4:p-FRS binds GRB2:SOS1 (Drosophila melanogaster)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
PI-3K cascade:FGFR4 (Drosophila melanogaster)
Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1:PIK3R1 [cytosol] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
SHC-mediated cascade:FGFR4 (Drosophila melanogaster)
Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Drosophila melanogaster)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Negative regulation of FGFR4 signaling (Drosophila melanogaster)
CBL ubiquitinates FRS2 and FGFR4 (Drosophila melanogaster)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Spry regulation of FGF signaling (Drosophila melanogaster)
SPRY2 binds GRB2 (Drosophila melanogaster)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Drosophila melanogaster)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Signaling by Insulin receptor (Drosophila melanogaster)
Insulin receptor signalling cascade (Drosophila melanogaster)
GRB2-1 binds SOS1 (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 binds p-Y427-SHC1 (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1:p-Y427-SHC1 [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
IRS-mediated signalling (Drosophila melanogaster)
PI3K Cascade (Drosophila melanogaster)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)
PI3K-containing complexes [cytosol] (Drosophila melanogaster)
Activated FGFR bound to PI3K [cytosol] (Drosophila melanogaster)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Drosophila melanogaster)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Drosophila melanogaster)
Active FLT3: GRB2 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
SOS-mediated signalling (Drosophila melanogaster)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Signal attenuation (Drosophila melanogaster)
GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Drosophila melanogaster)
GRB2-1:p-4S-SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2-1:p-4S-SOS1:p-Y427-SHC1 [cytosol] (Drosophila melanogaster)
GRB2-1:p-4S-SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Drosophila melanogaster)
GRB2-1:p-4S-SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Drosophila melanogaster)
GRB2-1:p-4S-SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Drosophila melanogaster)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Drosophila melanogaster)
GRB2-1:p-4S-SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Drosophila melanogaster)
GRB2-1:SOS1:p-Y427-SHC1 [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2-1:p-4S-SOS1:p-Y427-SHC1 [cytosol] (Drosophila melanogaster)
GRB2-1:p-4S-SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Signaling by NTRKs (Drosophila melanogaster)
Signaling by NTRK1 (TRKA) (Drosophila melanogaster)
Signalling to ERKs (Drosophila melanogaster)
Signalling to RAS (Drosophila melanogaster)
GRB2-1:SOS1 binds p-Y-SHC (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1:p-Y-SHC [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Signaling by PDGF (Drosophila melanogaster)
Downstream signal transduction (Drosophila melanogaster)
GRB2:SOS1 complex binds to the active receptor (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Drosophila melanogaster)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Signaling by SCF-KIT (Drosophila melanogaster)
Activation of RAS by p-KIT bound SOS1 (Drosophila melanogaster)
GRB2:SOS1:p-KIT complex [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Regulation of KIT signaling (Drosophila melanogaster)
Recruitment of CBL to KIT (Drosophila melanogaster)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Drosophila melanogaster)
Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Drosophila melanogaster)
GRB2:SOS1:p-KIT complex [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Drosophila melanogaster)
GRB2:SOS1:p-KIT complex [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Drosophila melanogaster)
IGF1R signaling cascade (Drosophila melanogaster)
IRS-related events triggered by IGF1R (Drosophila melanogaster)
IRS-mediated signalling (Drosophila melanogaster)
PI3K Cascade (Drosophila melanogaster)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)
PI3K-containing complexes [cytosol] (Drosophila melanogaster)
Activated FGFR bound to PI3K [cytosol] (Drosophila melanogaster)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Drosophila melanogaster)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Drosophila melanogaster)
Active FLT3: GRB2 [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
SOS-mediated signalling (Drosophila melanogaster)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
SHC-related events triggered by IGF1R (Drosophila melanogaster)
GRB2-1:SOS1 binds p-3Y-SHC1 (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1:p-3Y-SHC1 [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Drosophila melanogaster)
Signaling by Rho GTPases (Drosophila melanogaster)
RHO GTPase Effectors (Drosophila melanogaster)
RHO GTPases Activate WASPs and WAVEs (Drosophila melanogaster)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Drosophila melanogaster)
Mother filament:branching complex [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Drosophila melanogaster)
SH3 domain proteins [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Drosophila melanogaster)
SH3 domain proteins [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Detachment of WASP/WAVE (Drosophila melanogaster)
Mother filament:branching complex [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Drosophila melanogaster)
SH3 domain proteins [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Drosophila melanogaster)
SH3 domain proteins [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
RHO GTPase cycle (Drosophila melanogaster)
RHOU GTPase cycle (Drosophila melanogaster)
RHOU binds effectors at the plasma membrane (Drosophila melanogaster)
RHOU effectors [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
RHOU:GTP:RHOU effectors [plasma membrane] (Drosophila melanogaster)
RHOU effectors [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Vesicle-mediated transport (Drosophila melanogaster)
Membrane Trafficking (Drosophila melanogaster)
Clathrin-mediated endocytosis (Drosophila melanogaster)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
BAR domain proteins recruit dynamin (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Cargo recognition for clathrin-mediated endocytosis (Drosophila melanogaster)
Epsin family proteins bind ubiquitinated cargo (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Clathrin recruits PIK3C2A (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
Endophilins recruit synaptojanins to the clathrin-coated pit (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
F- and N- BAR domain proteins bind the clathrin-coated pit (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
RAB5 and GAPVD1 bind AP-2 (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
drk [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q08012
Gene Names
drk
Reference Genes
BioGPS Gene:36497 drk
CTD Gene:36497 drk
ENSEMBL:FBgn0004638
Flybase:FBgn0004638
KEGG Gene (Drosophila melanogaster):Dmel_CG6033 drk
Monarch:36497 drk
NCBI Gene:36497 drk
UCSC:Q08012 drk
Reference Transcript
RefSeq:NM_057510.4 drk
RefSeq:NM_165994.2 drk
RefSeq:NM_165998.2 drk
RefSeq:NM_165995.2 drk
RefSeq:NM_165996.2 drk
Other Identifiers
153747_at
1625475_s_at
36497
GO:0001784
GO:0005118
GO:0005154
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005886
GO:0007165
GO:0007173
GO:0007265
GO:0007426
GO:0007427
GO:0007465
GO:0007476
GO:0007605
GO:0007614
GO:0008022
GO:0008180
GO:0008286
GO:0008293
GO:0008306
GO:0008355
GO:0008543
GO:0009887
GO:0016020
GO:0016192
GO:0022414
GO:0023052
GO:0030154
GO:0030159
GO:0030707
GO:0032991
GO:0043226
GO:0043408
GO:0045202
GO:0045500
GO:0045793
GO:0048010
GO:0048260
GO:0048468
GO:0048856
GO:0048870
GO:0050877
GO:0060090
GO:0060429
GO:0070374
GO:0098793
GO:1904263
Participates
as a component of
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
GRB2-1:VAV1 [cytosol] (Drosophila melanogaster)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Drosophila melanogaster)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
GRB2-1:p-4S-SOS1 [cytosol] (Drosophila melanogaster)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Drosophila melanogaster)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Drosophila melanogaster)
p-Y371-CBL:GRB2 [cytosol] (Drosophila melanogaster)
CBL:GRB2 [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Drosophila melanogaster)
GRB2:Phospho-GAB1(partially dephosphorylated) [cytosol] (Drosophila melanogaster)
pFAK:Grb2:Sos [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1 [cytosol] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
Active FLT3: GRB2 [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1 [cytosol] (Drosophila melanogaster)
as a member of
RHOU effectors [cytosol] (Drosophila melanogaster)
SH3 domain proteins [cytosol] (Drosophila melanogaster)
as an input of
p-5Y-RET complexes bind GRB2 (Drosophila melanogaster)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Drosophila melanogaster)
SPRY2 binds GRB2 (Drosophila melanogaster)
CBL binds to GRB2 (Drosophila melanogaster)
GRB2-1 binds SOS1 (Drosophila melanogaster)
Binding of GRB2 to GAB1 (Drosophila melanogaster)
Other forms of this molecule
drk [cytosol]
drk [plasma membrane]
Inferred From
GRB2 [cytosol]
(Homo sapiens)
GRB2-1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_725306.1
,
NP_725302.1
,
NP_725303.1
,
NP_476858.1
,
NP_725304.1
Flybase
FBgn0004638
PRO
Q08012
PDB
2A37
,
2A36
,
7Y4N
,
2AZS
,
2AZV
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P26675 Sos
4
SOS [cytosol]
(R-DME-205953)
phospho-Sos [cytosol]
(R-DME-109821)
Sos [cytosol]
(R-DME-167221)
Sos [cytosol]
(R-DME-64847)
0.692
3
UniProt:Q9VZZ9
9
phospho-dos [cytosol]
(R-DME-8855306)
phospho-dos [cytosol]
(R-DME-9677149)
phospho-dos [cytosol]
(R-DME-8855574)
phospho-dos [cytosol]
(R-DME-180496)
dos [cytosol]
(R-DME-508239)
phospho-dos [cytosol]
(R-DME-2685615)
phospho-dos [cytosol]
(R-DME-180344)
phospho-dos [cytosol]
(R-DME-912529)
dos [cytosol]
(R-DME-179795)
0.667
6
UniProt:Q9VWM7 Q9VWM7
0.488
2
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