Reactome | STON2 [cytosol]

STON2 [cytosol]

Stable Identifier

R-DME-8862856

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

Q24212

Locations in the PathwayBrowser

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Vesicle-mediated transport (Drosophila melanogaster)

- Membrane Trafficking (Drosophila melanogaster)
  - Clathrin-mediated endocytosis (Drosophila melanogaster)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        STON2,1 [cytosol] (Drosophila melanogaster)
        
        STON2 [cytosol] (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        STON2,1 [cytosol] (Drosophila melanogaster)
        
        STON2 [cytosol] (Drosophila melanogaster)
    - BAR domain proteins recruit dynamin (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
        
        STON2,1 [cytosol] (Drosophila melanogaster)
        
        STON2 [cytosol] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
        
        STON2,1 [cytosol] (Drosophila melanogaster)
        
        STON2 [cytosol] (Drosophila melanogaster)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Drosophila melanogaster)
      - CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
        
        STON2,1 [cytosol] (Drosophila melanogaster)
        
        STON2 [cytosol] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
        
        STON2,1 [cytosol] (Drosophila melanogaster)
        
        STON2 [cytosol] (Drosophila melanogaster)
    - Cargo recognition for clathrin-mediated endocytosis (Drosophila melanogaster)
      - COP9 and TOR1 deneddylate STON2 (Drosophila melanogaster)
        
        STON2,1 [cytosol] (Drosophila melanogaster)
        
        STON2 [cytosol] (Drosophila melanogaster)
      - STON2 binds SYT proteins (Drosophila melanogaster)
        
        STON2,1 [cytosol] (Drosophila melanogaster)
        
        STON2 [cytosol] (Drosophila melanogaster)
        
        STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
        
        STON2,1 [cytosol] (Drosophila melanogaster)
        
        STON2 [cytosol] (Drosophila melanogaster)
      - STON2 is neddylated (Drosophila melanogaster)
        
        STON2,1 [cytosol] (Drosophila melanogaster)
        
        STON2 [cytosol] (Drosophila melanogaster)
    - Clathrin recruits PIK3C2A (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
        
        STON2,1 [cytosol] (Drosophila melanogaster)
        
        STON2 [cytosol] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
        
        STON2,1 [cytosol] (Drosophila melanogaster)
        
        STON2 [cytosol] (Drosophila melanogaster)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        STON2,1 [cytosol] (Drosophila melanogaster)
        
        STON2 [cytosol] (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        STON2,1 [cytosol] (Drosophila melanogaster)
        
        STON2 [cytosol] (Drosophila melanogaster)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
        
        STON2,1 [cytosol] (Drosophila melanogaster)
        
        STON2 [cytosol] (Drosophila melanogaster)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        STON2,1 [cytosol] (Drosophila melanogaster)
        
        STON2 [cytosol] (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        STON2,1 [cytosol] (Drosophila melanogaster)
        
        STON2 [cytosol] (Drosophila melanogaster)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        STON2,1 [cytosol] (Drosophila melanogaster)
        
        STON2 [cytosol] (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
        
        STON2,1 [cytosol] (Drosophila melanogaster)
        
        STON2 [cytosol] (Drosophila melanogaster)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
        
        STON2,1 [cytosol] (Drosophila melanogaster)
        
        STON2 [cytosol] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
        
        STON2,1 [cytosol] (Drosophila melanogaster)
        
        STON2 [cytosol] (Drosophila melanogaster)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        STON2,1 [cytosol] (Drosophila melanogaster)
        
        STON2 [cytosol] (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        STON2,1 [cytosol] (Drosophila melanogaster)
        
        STON2 [cytosol] (Drosophila melanogaster)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
        
        STON2,1 [cytosol] (Drosophila melanogaster)
        
        STON2 [cytosol] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        STON2,1:SYT dimers [plasma membrane] (Drosophila melanogaster)
        
        STON2,1 [cytosol] (Drosophila melanogaster)
        
        STON2 [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q24212

Reference Genes

BioGPS Gene:4379834

dbSNP Gene:4379834

ENSEMBL:FBgn0016975

Flybase:FBgn0016975

KEGG Gene (Drosophila melanogaster):Dmel_CG12473

Monarch:4379834

NCBI Gene:4379834

UCSC:Q24212

Reference Transcript

Other Identifiers

1625007_a_at

7227.FBpp0291230

ABI31012.2

AHN60009.1

EAA46059.3

EntrezGene:4379834

FBgn0016975

FBpp0291230

FBpp0291231

FBpp0310530

FBtr0302020

FBtr0302021

FBtr0344111

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005856

GO:0006810

GO:0006897

GO:0007267

GO:0007268

GO:0008021

GO:0008150

GO:0016192

GO:0030054

GO:0030100

GO:0030139

GO:0031410

GO:0043226

GO:0045202

GO:0048488

GO:0048489

GO:0048786

GO:0048788

GO:0097110

GO:0099504

GO:1900242

IPR012320

IPR017110

IPR028565

IPR036168

NM_001042853.3

NM_001042854.3

NM_001298610.1

NP_001036318.2

NP_001036319.2

NP_001285539.1

PF00928

U54982

UPI0001BFFF28

X2JGF5

Participant Of

hasMember

STON2,1 [cytosol]

Other forms of this molecule

NEDD8-STON2 [cytosol]

NEDD8-STON1 [cytosol]

STON1 [cytosol]

Inferred From

STON2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001285539.1, NP_001036319.2, NP_001036318.2

Flybase

FBgn0016975

PRO

Q24212

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21521	10	SYT2 [clathrin-coated endocytic vesicle membrane] (R-DME-8869116) SYT1 [clathrin-coated endocytic vesicle membrane] (R-DME-8869113) SYT8 [clathrin-coated endocytic vesicle membrane] (R-DME-8869119) SYT8 [plasma membrane] (R-DME-5216119) SYT2 [plasma membrane] (R-DME-168795) SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-DME-917741) SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane] (R-DME-210536) SYT1 [clathrin-sculpted glutamate transport vesicle membrane] (R-DME-372514) SYT1 [plasma membrane] (R-DME-168786) SYT1 [clathrin-sculpted monoamine transport vesicle membrane] (R-DME-372508)	0.623	5