Reactome | Syb [plasma membrane]

Syb [plasma membrane]

Stable Identifier

R-DME-8867599

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

plasma membrane

Synonyms

VAMP3, P18489

Locations in the PathwayBrowser

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Vesicle-mediated transport (Drosophila melanogaster)

- Membrane Trafficking (Drosophila melanogaster)
  - Clathrin-mediated endocytosis (Drosophila melanogaster)
    - BAR domain proteins recruit dynamin (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        Syb [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        Syb [plasma membrane] (Drosophila melanogaster)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Drosophila melanogaster)
      - CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        Syb [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        Syb [plasma membrane] (Drosophila melanogaster)
    - Cargo recognition for clathrin-mediated endocytosis (Drosophila melanogaster)
      - PICALM binds R-SNAREs (Drosophila melanogaster)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        Syb [plasma membrane] (Drosophila melanogaster)
        
        VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        Syb [plasma membrane] (Drosophila melanogaster)
    - Clathrin recruits PIK3C2A (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        Syb [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        Syb [plasma membrane] (Drosophila melanogaster)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        Syb [plasma membrane] (Drosophila melanogaster)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        Syb [plasma membrane] (Drosophila melanogaster)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        Syb [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        Syb [plasma membrane] (Drosophila melanogaster)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        Syb [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        Syb [plasma membrane] (Drosophila melanogaster)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        Syb [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        PICALM:VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)
        
        Syb [plasma membrane] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:P18489

Gene Names

Syb

Reference Genes

BioGPS Gene:36080 Syb

ENSEMBL:FBgn0003660

FlyBase:FBgn0003660

KEGG:dme:Dmel_CG12210 Syb

Monarch:36080 Syb

NCBI Gene:36080 Syb

UCSC:P18489 Syb

Reference Transcript

Other Identifiers

141625_at

1626835_at

1635944_a_at

1637089_at

36080

GO:0000149

GO:0005484

GO:0005515

GO:0005886

GO:0006906

GO:0007269

GO:0008021

GO:0016020

GO:0016081

GO:0016192

GO:0019905

GO:0030672

GO:0031201

GO:0031340

GO:0031410

GO:0045202

GO:0060090

GO:0061024

Participates

as a candidate of

as a member of

VAMP2,3,8 [plasma membrane] (Drosophila melanogaster)

Other forms of this molecule

Syb [clathrin-sculpted monoamine transport vesicle membrane]

Syb [plasma membrane]

Syb [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]

Syb [clathrin-sculpted glutamate transport vesicle membrane]

Syb [specific granule membrane]

Syb [plasma membrane]

Syb [azurophil granule membrane]

Syb [tertiary granule membrane]

Syb [clathrin-coated endocytic vesicle membrane]

Syb [secretory granule membrane]

Syb [cytosol]

Syb [trans-Golgi network membrane]

Syb [transport vesicle]

Syb [cytoplasmic vesicle membrane]

Syb [lysosomal membrane]

Syb [Golgi membrane]

Syb [cytoplasmic vesicle membrane]

Syb [secretory granule membrane]

Inferred From

VAMP3 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001137634.1, NP_523680.1, NP_001286278.1, NP_724906.1, NP_001137633.1

ENSEMBL

FBtr0273274, FBgn0003660, FBpp0271782

PRO

P18489

FlyBase

FBgn0003660

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q24547	6	Syx1A [cytosol] (R-DME-9609866) phospho-Syx1A [cytosol] (R-DME-114681) Syx1A [cytosol] (R-DME-114505) Syx1A [plasma membrane] (R-DME-181519) Syx1A [plasma membrane] (R-DME-449131) Syx1A [plasma membrane] (R-DME-449128)	0.731	5
UniProt:Q9W1I8	3	Snap29 [Golgi membrane] (R-DME-6810997) Snap29 [plasma membrane] (R-DME-2029020) Snap29 [azurophil granule membrane] (R-DME-6799359)	0.547	2
UniProt:Q9VH76	3	Snap24 [tertiary granule membrane] (R-DME-6806142-2) Snap24 [specific granule membrane] (R-DME-6806154-2) Snap24 [plasma membrane] (R-DME-2029017-2)	0.547	2

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