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phospho-Shc [cytosol]
Stable Identifier
R-DME-912321
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
p-Y349,Y350,Y427-SHC1, Q9V3C8
Locations in the PathwayBrowser
Expand all
Developmental Biology (Drosophila melanogaster)
Nervous system development (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
RET signaling (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
SHC1 in the RET complex is phosphorylated (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
p-5Y-RET complexes bind GRB2 (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
RAS GEFs promote RAS nucleotide exchange (Drosophila melanogaster)
RAS GEFs [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by ERBB2 (Drosophila melanogaster)
SHC1 events in ERBB2 signaling (Drosophila melanogaster)
Activated PKC phosphorylates SHC1 (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Drosophila melanogaster)
IGF1R signaling cascade (Drosophila melanogaster)
SHC-related events triggered by IGF1R (Drosophila melanogaster)
GRB2-1:SOS1 binds p-3Y-SHC1 (Drosophila melanogaster)
GRB2-1:SOS1:p-3Y-SHC1 [cytosol] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9V3C8
Gene Names
Shc
Reference Genes
BioGPS Gene:44052 Shc
CTD Gene:44052 Shc
ENSEMBL:FBgn0015296
Flybase:FBgn0015296
KEGG Gene (Drosophila melanogaster):Dmel_CG3715 Shc
Monarch:44052 Shc
NCBI Gene:44052 Shc
UCSC:Q9V3C8 Shc
Reference Transcript
RefSeq:NM_079944.3 Shc
Other Identifiers
143792_at
1623967_at
44052
GO:0001751
GO:0002376
GO:0005154
GO:0005886
GO:0007163
GO:0007169
GO:0007173
GO:0007298
GO:0007362
GO:0007426
GO:0007427
GO:0007474
GO:0008069
GO:0008078
GO:0008293
GO:0008543
GO:0019901
GO:0022414
GO:0023052
GO:0030154
GO:0030971
GO:0035011
GO:0035556
GO:0048010
GO:0048856
GO:0048870
GO:0051179
GO:0098542
GO:1904263
GO:1905815
Participates
as an input of
GRB2-1:SOS1 binds p-3Y-SHC1 (Drosophila melanogaster)
Activated PKC phosphorylates SHC1 (Drosophila melanogaster)
as a component of
GRB2-1:SOS1:p-3Y-SHC1 [cytosol] (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Drosophila melanogaster)
Other forms of this molecule
Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
Shc [cytosol]
Shc [cytosol]
Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [plasma membrane]
phospho-Shc [plasma membrane]
phospho-Shc [cytosol]
Inferred From
p-3Y-SHC1 [cytosol]
(Homo sapiens)
p-3Y-SHC1-1,p-3Y-SHC1-2 [cytosol]
(Homo sapiens)
p-Y349,Y350,Y427-SHC1-1 [cytosol]
(Homo sapiens)
p-Y349,Y350,Y427-SHC1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 427 (in Homo sapiens)
Coordinate
427
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 349 (in Homo sapiens)
Coordinate
349
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 350 (in Homo sapiens)
Coordinate
350
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_524683.2
Flybase
FBgn0015296
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9VQ77 Q9VQ77
0.488
2
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