Vimar activates Miro

Stable Identifier
R-DME-9693775
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
mitochondrial outer membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Vimar activates Miro
Vimar, a Drosophila melanogaster orthologue of human RAP1GDS1, is a mitochondrial outer membrane atypical guanine nucleotide exchange factor (GEF) that activates mitochondria-associated atypical RHO GTPase Miro, an orthologue of human RHOT1 and RHOT2. Vimar catalyzes GDP to GTP exchange, resulting in formation of the active Miro:GTP complex (Ding et al. 2016).
Literature References
PubMed ID Title Journal Year
27716788 Vimar Is a Novel Regulator of Mitochondrial Fission through Miro

Ding, L, Lei, Y, Han, Y, Li, Y, Ji, X, Liu, L

PLoS Genet. 2016
Participants
Input
Output
Catalyst Activity

guanyl-nucleotide exchange factor activity of Vimar [mitochondrial outer membrane]

Physical Entity
Vimar [mitochondrial outer membrane] (Drosophila melanogaster)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
RHOT2 GEFs activate RHOT2 (Homo sapiens)
RHOT1 GEFs activate RHOT1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2020-07-14)
Reviewed
Schrader, M  (2021-02-09)
Castro, IG  (2021-02-09)
Created
Orlic-Milacic, M  (2020-07-06)
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